178600-20-9

Usage

Uses

Used in Organic Chemistry Research:
(2E,4E,6E)-7-(3,5-Di-tert-butylphenyl)-3-methylocta-2,4,6-trienoic acid is used as a research compound for exploring its chemical properties and potential reactions. Its complex structure with multiple double bonds and functional groups makes it a candidate for studies in synthetic organic chemistry, where it could be used to investigate new reaction pathways or to develop novel synthetic methods.
Used in Material Science:
In the field of material science, (2E,4E,6E)-7-(3,5-Di-tert-butylphenyl)-3-methylocta-2,4,6-trienoic acid may be utilized as a precursor or intermediate in the synthesis of advanced materials. Its structural features could be exploited to create new polymers or composites with specific properties, such as improved thermal stability, mechanical strength, or chemical resistance.
Used in Pharmaceutical Development:
Although not explicitly stated, the complex structure of (2E,4E,6E)-7-(3,5-Di-tert-butylphenyl)-3-methylocta-2,4,6-trienoic acid could also suggest potential applications in pharmaceutical development. (2E,4E,6E)-7-(3,5-Di-tert-butylphenyl)-3-methylocta-2,4,6-trienoic acid might be used as a lead molecule in drug discovery, where its interactions with biological targets could be studied to develop new therapeutic agents, particularly if its carboxylic acid group allows for easy derivatization and modification to enhance its biological activity.
Used in Analytical Chemistry:
(2E,4E,6E)-7-(3,5-Di-tert-butylphenyl)-3-methylocta-2,4,6-trienoic acid could be employed as a reference material or standard in analytical chemistry. Its distinct structural features might be used to calibrate instruments or to validate analytical methods, ensuring accurate measurements and comparisons in various chemical analyses.

Upstream product

• 16225-26-6 3,5-di-tert-butylbenzoic acid 
• 178688-27-2 ethyl (2E, 4E, 6E)-7-(3,5-di-t-butylphenyl)-3-methylocta-2,4,6-trienoate 
• 1756-31-6 1-(3,5-di-tert-butylphenyl)ethanone 
• 178688-25-0 (E)-3-(3,5-Di-tert-butyl-phenyl)-but-2-enal 
• 178688-23-8 (E)-3-(3,5-Di-tert-butyl-phenyl)-but-2-enenitrile 
• 178688-24-9 (Z)-3-(3,5-Di-tert-butyl-phenyl)-but-2-enenitrile 
• 178688-26-1 3-(3,5-Di-t-butylphenyl)but-2-enal 
• 41891-54-7 diethyl 3-(ethoxycarbonyl)-3-methylprop-2-en-yl phosphate 
• 178688-28-3 ethyl (2E, 4E, 6Z)-7-(3,5-di-t-butylphenyl)-3-methylocta-2,4,6-trienoate 
• 180740-59-4 (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enenitrile 
• 180740-61-8 (2E,4E,6E)-7-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-3-methyl-octa-2,4,6-trienoic acid ethyl ester 
• 279215-39-3 ethyl (2E,4E,6E)-7-[3-tert-butyl-5-(1,1-dimethylethyl-2-p-toluenesulfonylhydrazone)phenyl]-3-methylocta-2,4,6-trienoate 
• 180740-60-7 (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal 
• 180740-58-3 1-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-ethanone 

Relevant academic research and scientific papers

Trienoic retinoid compounds and methods

Novel trienoic retinoid compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.

Synthesis and characterization of a highly potent and selective isotopically labeled retinoic acid receptor ligand, ALRT1550

The syntheses of two labeled homologues of (2E,4E,6E)-7-(3,5-di-tert- butylphenyl)-3-methylocta-2,4,6-trienoic acid (ALRT1550, 2), [13CD3]ALRT1550 (3) and [3H]ALRT1550 (4), are described in this report. ALRT1550 is an exceptionally potent antiproliferative agent which is currently in phase I/II clinical trials for acute chemotherapy. Both homologues were prepared from commercially available 3,5-di-tert-butylbenzoic acid. Homologue [13CD3]ALRT1550 was labeled at the 7-position of the trienoic acid chain via addition of [13CD3]MgI to a Weinreb amide precursor. The preparation of [3H]ALRT1550 utilized novel methodology to synthesize a sterically hindered and site-specific tritium-labeled tert- butyl group. Saturation binding and Scatchard analysis of this ligand at the retinoic acid receptors are also described, along with competition binding (K(i)) values for a series of known retinoids using [3H]ALRT1550 or [3H]ATRA as the labeled probes.

Trienoic retinoid compounds and methods

Novel trienoic compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.

Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells

Retinoic acid receptor (RAR) active retinoids have proven therapeutically useful for treating certain cancers and dermatological diseases. Herein, we describe the discovery of two new RAR active trienoic acid retinoids, (2E,4E,6E)-7-(3,5-di-tert-butylphen