178688-27-2

Usage

Uses

Used in Chemical Industry:
2,4,6-Octatrienoic acid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, ethyl ester, (2E,4E,6E)is used as a chemical intermediate for the synthesis of various compounds and materials due to its unique structure and functional groups.
Used in Pharmaceutical Industry:
2,4,6-Octatrienoicacid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, ethyl ester, (2E,4E,6E)may be utilized as a precursor in the development of pharmaceuticals, given its potential to be modified and incorporated into drug molecules for specific therapeutic applications.
Used in Research and Development:
2,4,6-Octatrienoic acid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, ethyl ester, (2E,4E,6E)is used as a research compound to study its properties, reactivity, and potential applications in various fields, including material science and organic chemistry.

Upstream product

• 279215-39-3 ethyl (2E,4E,6E)-7-[3-tert-butyl-5-(1,1-dimethylethyl-2-p-toluenesulfonylhydrazone)phenyl]-3-methylocta-2,4,6-trienoate 
• 16225-26-6 3,5-di-tert-butylbenzoic acid 
• 178688-23-8 (E)-3-(3,5-Di-tert-butyl-phenyl)-but-2-enenitrile 
• 1756-31-6 1-(3,5-di-tert-butylphenyl)ethanone 
• 180740-61-8 (2E,4E,6E)-7-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-3-methyl-octa-2,4,6-trienoic acid ethyl ester 
• 180740-60-7 (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal 
• 180740-58-3 1-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-ethanone 
• 180740-62-9 (2E,4E,6E)-7-[3-tert-Butyl-5-(2-hydroxy-1,1-dimethyl-ethyl)-phenyl]-3-methyl-octa-2,4,6-trienoic acid ethyl ester 
• 180740-63-0 (2E,4E,6E)-7-[3-tert-Butyl-5-(1,1-dimethyl-2-oxo-ethyl)-phenyl]-3-methyl-octa-2,4,6-trienoic acid ethyl ester 
• 180740-55-0 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanone 
• 180740-54-9 1-{3-tert-Butyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-ethanol 
• 180740-57-2 1-[3-tert-butyl-5-(2-hydroxy-1,1-dimethylethyl)phenyl]ethanone 
• 180740-53-8 1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]ethanol 
• 41891-54-7 diethyl 3-(ethoxycarbonyl)-3-methylprop-2-en-yl phosphate 

Downstream Products

• 178600-20-9 LGD₁₅₅₀ 

Relevant academic research and scientific papers

Synthesis and characterization of a highly potent and selective isotopically labeled retinoic acid receptor ligand, ALRT1550

The syntheses of two labeled homologues of (2E,4E,6E)-7-(3,5-di-tert- butylphenyl)-3-methylocta-2,4,6-trienoic acid (ALRT1550, 2), [13CD3]ALRT1550 (3) and [3H]ALRT1550 (4), are described in this report. ALRT1550 is an exceptionally potent antiproliferative agent which is currently in phase I/II clinical trials for acute chemotherapy. Both homologues were prepared from commercially available 3,5-di-tert-butylbenzoic acid. Homologue [13CD3]ALRT1550 was labeled at the 7-position of the trienoic acid chain via addition of [13CD3]MgI to a Weinreb amide precursor. The preparation of [3H]ALRT1550 utilized novel methodology to synthesize a sterically hindered and site-specific tritium-labeled tert- butyl group. Saturation binding and Scatchard analysis of this ligand at the retinoic acid receptors are also described, along with competition binding (K(i)) values for a series of known retinoids using [3H]ALRT1550 or [3H]ATRA as the labeled probes.

Trienoic retinoid compounds and methods

Novel trienoic compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.

Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells

Retinoic acid receptor (RAR) active retinoids have proven therapeutically useful for treating certain cancers and dermatological diseases. Herein, we describe the discovery of two new RAR active trienoic acid retinoids, (2E,4E,6E)-7-(3,5-di-tert-butylphen