178606-72-9Relevant academic research and scientific papers
NOVEL SULFAMOYL-PHENYL-UREIDO COMPOUNDS AND THEIR USE AS MEDICAMENT
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Page/Page column 10, (2010/08/08)
The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated
Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents
Leban, Johann,Pegoraro, Stefano,Dormeyer, Matthias,Lanzer, Michael,Aschenbrenner, Andrea,Kramer, Bernd
, p. 1979 - 1982 (2007/10/03)
The high throughput in silico screening of a virtual library into the structure of the P. falciparum lactate dehydrogenase (LDH) with the 4SCan technology yielded a series of biphenyl urea compounds. These were chemically optimized to a new structural class of potent antimalarial agents. The compounds did not inhibit plasmodium LDH enough to fully explain their potency. Therefore we conclude that an unknown mode of action may be the cause of the antimalarial activity.
