178666-52-9Relevant academic research and scientific papers
8-Prenylflavanones through Microwave Promoted Tandem Claisen Rearrangement/6-endo-trig Cyclization and Cross Metathesis
Schultze, Christiane,Fo?, Stefan,Schmidt, Bernd
, p. 7373 - 7384 (2020/11/30)
Prenylated flavanones were obtained from ortho-allyloxy chalcones through a one-pot sequence of Claisen rearrangement and 6-endo-trig cyclization, followed by olefin cross metathesis of the intermediate allyl flavanones with 2-methyl-2-butene. The synthet
Synthesis and biological evaluation of 3-alkoxy analogues of flavone-8-acetic acid
Gobbi, Silvia,Rampa, Angela,Bisi, Alessandra,Belluti, Federica,Piazzi, Lorna,Valenti, Piero,Caputo, Anna,Zampiron, Antonella,Carrara, Maria
, p. 3662 - 3669 (2007/10/03)
New analogues of flavone-8-acetic acid were synthesized, bearing an alkoxy group in position 3 and different substituents on the benzene ring in position 2 of the flavone nucleus. The compounds were tested for direct cytotoxicity against four human tumor cell lines and for indirect antitumor effects by measuring their ability to enhance lytic properties of murine macrophages and human monocytes. Though direct toxicity was very low, the compounds were able to induce significant indirect toxicity. Notably, most of them (4c, 4d, 4e, 4f, 4h, 4i, 4m, 4n, and 4o) showed important activity on human monocytes and could be regarded as the first flavone derivatives endowed with such activity. Particularly interesting seem to be compounds 4m and 4n, which showed IC 50 values up to 7 times higher than DMXAA, which has now completed phase I clinical trials.
