178676-97-6

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 140-88-5 ethyl acrylate 
• 32723-67-4 3-methyl-4-anisaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 288311-06-8 5-(4-methoxy-3-methyl-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-pentanenitrile 
• 288310-74-7 1,1,1-trifluoro-4-(4-methoxy-3-methyl-phenyl)-butan-2-one 
• 288311-07-9 methyl 4-(4-methoxy-3-methyl-phenyl)-2-oxo-butyrate 
• 344308-94-7 3-(4-Methoxy-3-methyl-phenyl)-propionyl chloride 
• 22442-47-3 3-(4-methoxy-3-methylphenyl)propinoic acid 
• 140841-05-0 ethyl 3-(4-hydroxy-3-methylphenyl)propanoate 
• 178676-98-7 ethyl 3-(4-methoxy-3-methylphenyl)propinoate 

Relevant academic research and scientific papers

S,O-Ligand-Promoted Pd-Catalyzed C?H Olefination of Anisole Derivatives

The C?H olefination of substituted anisole derivatives by a Pd/S,O-ligand catalyst is reported. The reaction proceeds under mild conditions with a broad range of substituted aryl ethers bearing both electron donating and withdrawing substituents at ortho,

Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C-H Annulation and Their Application to Pd-Catalyzed Aerobic C-H Alkenylation

A new class of bidentate ligands was prepared by a modular approach involving Rh-catalyzed C-H annulation reactions. The resulting conformationally constrained ligands enabled the Pd-catalyzed C-H alkenylation at electron-rich and sterically less hindered positions of electron-rich arenes while promoting the facile oxidation of Pd(0) intermediates by oxygen. This newly introduced ligand class is complementary to the ligands developed for Pd-catalyzed oxidative reactions and may find broad application in transition-metal-catalyzed reactions.

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors

A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulted in a series of benzoic acid analogues that are potent inhibitors of HIV-1 replication against a panel of HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Furthermore, the combination of good antiviral potency, a broad spectrum of activity, and an excellent pharmacokinetic profile provides strong justification for the further development of compound 7 as a potential treatment for wild type and NNRT1-resistant HIV-1 infection.

Benzocycloalkene compounds, their production and use

A compound of the formula wherein R1and R2are H, a hydrocarbon group or a heterocyclic group, or R1and R2are combinedly a spiro ring; R3is a hydrocarbon group, a substituted amino group, a substituted

Regioselective intramolecular oxidation of phenols and anisoles by dioxiranes generated in situ

A novel method for regioselective oxidation of phenols and anisoles has been developed in which dioxiranes, generated in situ from ketones and Ozone, oxidize phenol derivatives in an intramolecular fashion. A series of ketones with electron-withdrawing groups, such as CF3, COOMe, and CH2Cl, were attached to phenols, anisoles, or aryl rings via a C2 or C3 methylene linker. In a homogeneous solvent system of CH3CN and H2O, oxidation of phenol derivatives 1-10 afforded spiro 2-hydroxydienones in 24-55% yields regardless of the presence of other substituents (ortho Me, meta Me or Br) on the aryl ring and the length of the linker. Experimental evidences were provided to support the mechanism that involves a regioselective π bond epoxidation of aryl rings followed by epoxide rearrangement and hemiketal formation.