1787252-03-2 Usage
Uses
Used in Chemical Biology:
DBCO-NHS ester is used as a crosslinker for the efficient labeling of biomolecules such as proteins, nucleic acids, and carbohydrates. It enables the synthesis of complex molecular assemblies and accurate labeling for research applications.
Used in Bioconjugation:
DBCO-NHS ester is used as a reagent for bioconjugation to attach azide-modified molecules to biomolecules. The DBCO group selectively reacts with azide groups via the copper-free click chemistry reaction, while the NHS ester group reacts with primary amines, facilitating the conjugation process.
Used in Diagnostic Applications:
DBCO-NHS ester is used as a labeling agent for the detection and analysis of biomolecules in diagnostic assays. Its efficient labeling capabilities allow for accurate identification and quantification of target molecules in various diagnostic tests.
Used in Drug Development:
DBCO-NHS ester is used as a tool in the development of new drugs and drug delivery systems. Its ability to label and modify biomolecules can help researchers study the interactions between drugs and their targets, as well as develop targeted drug delivery systems for improved therapeutic outcomes.
Used in Materials Science:
DBCO-NHS ester is used as a component in the development of biocompatible materials and coatings. Its ability to covalently attach biomolecules to surfaces can be utilized to create materials with specific biological functions or improved biocompatibility for medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1787252-03-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,8,7,2,5 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1787252-03:
(9*1)+(8*7)+(7*8)+(6*7)+(5*2)+(4*5)+(3*2)+(2*0)+(1*3)=202
202 % 10 = 2
So 1787252-03-2 is a valid CAS Registry Number.
1787252-03-2Relevant academic research and scientific papers
Copper-free catalytic click chemical module molecule and application of copper-free catalytic click chemical module molecule in medicine
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Paragraph 0099, (2017/08/28)
The invention relates to the field of chemistry and a preparation, and more specifically relates to preparation of a copper-free catalytic click chemical module molecule and an application of the copper-free catalytic click chemical module molecule in construction of a drug delivery carrier and surface multifunctional modification. According to the invention, a cyclooctyne derivative and a liposome matrix are used for forming stable liposome through a dispersing method; a physical effect is used for efficiently loading the gene treatment medicines or chemotherapeutics, furthermore, the stable drug liposome is formed; finally, through a click chemical reaction of copper-free catalysis, and the azide derivatives having different functions are modified to the surface of the drug liposome according to the requirement and the formation of a chemical bond. The method can avoid the toxicity of heavy metal copper ions, and overcomes the disadvantages of DNA degradation and protein denaturation brought by copper catalysis. Under condition that efficient and stable medicine carrying is guaranteed, the construction of the multifunctional drug delivery carrier with safety, stabilization and high efficiency can be obtained.
