178751-14-9

Upstream product

• 211732-82-0 Methanesulfonic acid (S)-1-methyl-2-{6-[(4-nitro-phenyl)-(phthalazin-1-yl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-ethyl ester 
• 1044569-46-1 1-hydrazinophthalazine 
• 196303-02-3 (5RS,7S)-7,8-dihydro-7-methyl-5-(4-nitrophenyl)-5H-1,3-dioxolo[4,5-G][2]benzopyran-5-ol 
• 211732-79-5 (S)-1-{6-[(4-Nitro-phenyl)-(phthalazin-1-yl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-propan-2-ol 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazepine AMPA antagonists

A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists.

Dihydro-2,3-benzodiazepine derivatives

Compounds having general formula (I) wherein R is hydrogen or C1 -C10 alkyl; X is an aromatic moiety selected from phenyl, thienyl, furyl, pyridyl, imidazolyl, benzimidazolyl, benzothiazolyl and phthalazinyl which is unsubstituted or