17880-88-5

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichloroquinoxaline-6-carbonyl chloride is used as a key intermediate in the synthesis of pharmaceuticals for its ability to facilitate the creation of complex organic molecules that can be used in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-Dichloroquinoxaline-6-carbonyl chloride is used as a precursor in the production of agrochemicals, contributing to the development of compounds that can enhance crop protection and yield.
Due to its hazardous nature, 2,3-Dichloroquinoxaline-6-carbonyl chloride is typically handled and used in a controlled laboratory environment to ensure safety and proper reaction conditions.

InChI:InChI=1/C9H4Cl2N2O2/c10-7-8(11)13-6-3-4(9(14)15)1-2-5(6)12-7/h1-3H,(H,14,15)

Upstream product

• 1919-43-3 2,3-dichloro-quinoxaline-6-carboxylic acid chloride 
• 14121-55-2 2,3-dihydroxy-6-quinoxalinecarboxylic acid 
• 619-05-6 3,4-diaminobenzoic acid 

Relevant academic research and scientific papers

Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols

A bioorthogonal ligation and cleavage method via reactions of chloroquinoxalines (CQ) and ortho-dithiophenols (DT) is presented. Double nucleophilic substitutions of ortho-dithiophenols to chloroquinoxalines provide conjugates containing tetracyclic benzo[5,6][1,4]dithiino[2,3-b]quinoxaline with strong built-in fluorescence together with release of the other functional molecules. Three cleavable linkers were designed and successfully used in release of the molecules containing biotin from the protein conjugates. The CQ-DT bioorthogonal reactions can be applied for the bioorthogonal ligations, bioorthogonal cleavages, and trans-tagging of proteins, and show advantages of readily accessible unnatural orthogonal groups, appealing reaction kinetics (k2≈1.3 m?1 s?1), excellent biocompatibility of orthogonal groups, and high stability of conjugates. This complements previous bioorthogonal reactions and is a new route for protein-fishing applications and in-gel fluorescence analysis.