178809-21-7

Usage

Uses

Used in Pharmaceutical Industry:
Flutamide is used as an antiandrogen medication for the treatment of prostate cancer, a condition where the growth and spread of cancer cells are influenced by androgen hormones. By blocking these hormones, Flutamide helps to slow down the progression of the disease and improve the patient's quality of life.
Additionally, Flutamide is used as a therapeutic agent for hirsutism, a medical condition characterized by excessive hair growth in women. The medication works by reducing the effects of androgen hormones, which are responsible for this abnormal hair growth, thereby helping to manage and alleviate the symptoms.

Upstream product

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Downstream Products

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Relevant academic research and scientific papers

Radical C(sp3)-H alkenylation, alkynylation and allylation of ethers and amides enabled by photocatalysis

An efficient radical addition/elimination reaction that enables selective incorporation of alkenyl, alkynyl and allyl functional groups into the C(sp3)-H bond under green reaction conditions is developed. The process is based on the catalytic formation of α-alkoxyl/α-amidyl radicals via the homolytic activation of the C(sp3)-H bond of ethers/amides with a catalytic amount of diarylketone in the presence of a household fluorescent light bulb. This simple reaction protocol features good functional group tolerance, scalability, convenient reagents and operating systems. Synthetic application of the method has been demonstrated via the preparation of natural products and different valuable synthones.

RENIN INHIBITORS

The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel

Intramolecular palladium-catalyzed aryl amination and aryl amidation

Upon treatment with a palladium catalyst and a suitable base, aromatic halides undergo intramolecular substitution to form five, six, and seven-membered rings. In a similar fashion aryl halides with pendant amides or sulfonamides are cyclized to form five and six-membered rings.