61698-07-5

Basic information

• Product Name: Benzenepropanenitrile, 2-broMo-
• Synonyms: Benzenepropanenitrile, 2-broMo-;2-Bromo-benzenepropanenitrile;3-(2-bromophenyl)propanenitrile;3-(2-BROMOPHENYL)PROPANENITRILE(WXC05287)
• CAS NO: 61698-07-5
• Molecular Formula: C₉H₈BrN
• Molecular Weight: 210.07052
• Mol File: 61698-07-5.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanenitrile, 2-broMo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanenitrile, 2-broMo-(61698-07-5)
• EPA Substance Registry System: Benzenepropanenitrile, 2-broMo-(61698-07-5)

Safety Data

• Hazardous Substances Data: 61698-07-5(Hazardous Substances Data)

Usage

General Description

Benzenepropanenitrile, 2-bromo- is a chemical compound with the molecular formula C9H8BrN. It is a colorless to pale yellow liquid with a strong, bitter almond odor. Benzenepropanenitrile, 2-bromo- is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a chemical intermediate and a reagent in organic synthesis. Benzenepropanenitrile, 2-bromo- is a highly reactive compound and should be handled with caution. It has the potential to cause irritation to the skin, eyes, and respiratory tract, and can be harmful if ingested or inhaled. Proper safety precautions should be taken when working with this chemical.

Upstream product

• 107-13-1 acrylonitrile 
• 88-65-3 2-bromobenzoic-acid 
• 55223-26-2 3-(2-bromophenyl)propanamide 
• 66191-86-4 3-(2-bromophenyl)propanoic acid,methyl ester 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 1074-16-4 2-bromophenylethyl alcohol 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 583-55-1 1-Bromo-2-iodobenzene 
• 75-05-8 acetonitrile 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 178809-30-8 3-(2-bromo-phenyl)-acrylonitrile 
• 99749-00-5 lithioacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 1445166-50-6 methyl 3-(4-((2-(2-cyanoethyl)phenyl)ethynyl)-2-fluorophenyl)propanoate 
• 1429427-39-3 3-(4-((2-(2-cyanoethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid 
• 83-33-0 inden-1-one 
• 2241982-86-3 3-(phenyl-2-d)propanenitrile-2,2-d2 
• 1310552-75-0 N-(3-(2-bromophenyl)propyl)-2,2,2-trifluoroacetamide 
• 1268863-01-9 3-(3,4-dihydroquinolin-1(2H)-yl)-2-phenylquinoxaline-6-carboxylic acid 
• 1268866-10-9 methyl 3-(3,4-dihydroquinolin-1(2H)-yl)-2-phenylquinoxaline-6-carboxylate 
• 1268866-08-5 methyl 3-(3-(2-bromophenyl)propylamino)-2-phenylquinoxaline-6-carboxylate 
• 1049762-70-0 3-(2-thiophen-3-yl-phenyl)-propionitrile 

Relevant articles and documents

Visible- And UV-Light-Induced Decarboxylative Radical Reactions of Benzoic Acids Using Organic Photoredox Catalysts

Photoinduced decarboxylative radical reactions of benzoic acids with electron-deficient alkenes, diborane, and acetonitrile under organic photoredox catalysis conditions and mild heating afforded adducts, arylboronate esters, and the reduction product, respectively. The reaction is thought to involve single-electron transfer promoted the generation of aryl radicals via decarboxylation. A diverse range of benzoic acids were found to be suitable substrates for this photoreaction. Only our two-molecule organic photoredox system can work well for the direct photoinduced decarboxylation of benzoic acids.

meta-Selective C?H Borylation of Benzylamine-, Phenethylamine-, and Phenylpropylamine-Derived Amides Enabled by a Single Anionic Ligand

Selective functionalization at the meta position of arenes remains a significant challenge. In this work, we demonstrate that a single anionic bipyridine ligand bearing a remote sulfonate group enables selective iridium-catalyzed borylation of a range of common amine-containing aromatic molecules at the arene meta position. We propose that this selectivity is the result of a key hydrogen bonding interaction between the substrate and catalyst. The scope of this meta-selective borylation is demonstrated on amides derived from benzylamines, phenethylamines and phenylpropylamines; amine-containing building blocks of great utility in many applications.

Discovery of TUG-770: A highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing.