178809-32-0

Usage

Properties

1. Molecular formula: C10H10BrN
2. Color: Colorless to pale yellow
3. State: Liquid at room temperature
4. Solubility: Insoluble in water, soluble in organic solvents
5. Toxicity: Toxic and irritating to skin, eyes, and respiratory system

Specific Content

Chemical compound
Nitrile derivative of 2-bromophenylbutane
Chiral compound
Used as a building block in organic synthesis
Intermediate in production of pharmaceuticals, agrochemicals, and other fine chemicals
Valuable in development of new compounds and materials.

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 1075-28-1 1-bromo-2-(3-bromopropyl)benzene 
• 66191-86-4 3-(2-bromophenyl)propanoic acid,methyl ester 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 165803-61-2 3-(2-bromophenyl)propyl methanesulfonate 
• 151-50-8 potassium cyanide 
• 107408-16-2 3-(o-bromophenyl)propanal 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 583-55-1 1-Bromo-2-iodobenzene 
• 143-33-9 sodium cyanide 

Downstream Products

• 123206-83-7 4-(2-Bromophenyl)-1-butanol 
• 178809-23-9 N-acetyl-4-(o-bromophenyl)butylamine 
• 178809-33-1 4-(o-bromophenyl)butylamine 

Relevant academic research and scientific papers

Highly Diastereoselective Synthesis of Medium-Sized Carbocycle-Fused Piperidines via Sequential Hydride Shift Triggered Double C(sp3)-H Bond Functionalization

Herein we report a diastereoselective synthesis of medium-sized carbocycle-fused piperidines via [1,n (n = 6, 7)]-[1,5]-sequential hydride shift triggered double C(sp3)-H bond functionalization. When cinnamylidene malonates having N,N-dibenzyl propylamine moiety were treated with 5 mol % of Yb(OTf)3, a [1,6]-[1,5]-sequential hydride shift/cyclization process proceeded to afford seven-membered carbocycle-fused piperidines with excellent diastereoselectivities. This sequential system was applicable to the synthesis of eight-membered carbocycle-fused piperidines by an unprecedented [1,7]-[1,5]-sequential hydride shift/cyclization process.

Metal-Free Enantioselective Oxidative Arylation of Alkenes: Hypervalent-Iodine-Promoted Oxidative C?C Bond Formation

The enantioselective oxyarylation of (E)-6-aryl-1-silyloxylhex-3-ene was achieved using a lactate-based chiral hypervalent iodine(III) reagent in the presence of boron trifluoride diethyl etherate. The silyl ether promotes the oxidative cyclization, and enhances the enantioselectivity. In addition, the corresponding aminoarylation was achieved.

Enantioselective halogenative semi-pinacol rearrangement: A stereodivergent reaction on a racemic mixture

An efficient, quantitative deracemization strategy for optically inactive allylic cycloalkanols has been achieved using the biphasic halogenative semi-pinacol reaction protocol. The resultant β-halo spiroketones, containing three contiguous stereogenic ce

RENIN INHIBITORS

The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

2-(1H-indolylsulfanyl)-aryl amine derivatives

The present invention relates to compounds of formula IV and their use.

Benzo[b]furane and benzo[b]thiophene derivatives

The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.

Intramolecular palladium-catalyzed aryl amination and aryl amidation

Upon treatment with a palladium catalyst and a suitable base, aromatic halides undergo intramolecular substitution to form five, six, and seven-membered rings. In a similar fashion aryl halides with pendant amides or sulfonamides are cyclized to form five and six-membered rings.