165803-61-2

Upstream product

• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 583-55-1 1-Bromo-2-iodobenzene 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 107408-16-2 3-(o-bromophenyl)propanal 
• 102540-15-8 methyl (2E)-3-(2-bromophenyl)-2-propenoate 
• 66191-86-4 3-(2-bromophenyl)propanoic acid,methyl ester 

Downstream Products

• 113163-20-5 1-bromo-2-(3-iodopropyl)benzene 
• 178809-32-0 4-(2-bromophenyl)butanenitrile 
• 199789-63-4 N-formyl-6-[3-(2-bromophenyl)propyl]-1,2,3,4-tetrahydropyridine 
• 178809-33-1 4-(o-bromophenyl)butylamine 
• 178809-23-9 N-acetyl-4-(o-bromophenyl)butylamine 
• 123206-84-8 4-(2-bromophenyl)butyraldehyde 
• 135966-97-1 2-{1-[3-(2-Bromo-phenyl)-propyl]-1H-indol-3-yl}-N,N-dipropyl-acetamide 

Relevant academic research and scientific papers

Pd(0)-Catalyzed Direct Inter- And Intramolecular C-H Functionalization of 4-Carboxyimidazoles

The palladium-catalyzed arylation and alkenylation of N -substituted methyl imidazole-4-carboxylates are described through inter- and intramolecular pathways. Both direct C2-H and C5-H arylation and alkenylation proceed under Pd(0)/Cu(I) cooperative catal

Metal-Free Enantioselective Oxidative Arylation of Alkenes: Hypervalent-Iodine-Promoted Oxidative C?C Bond Formation

The enantioselective oxyarylation of (E)-6-aryl-1-silyloxylhex-3-ene was achieved using a lactate-based chiral hypervalent iodine(III) reagent in the presence of boron trifluoride diethyl etherate. The silyl ether promotes the oxidative cyclization, and enhances the enantioselectivity. In addition, the corresponding aminoarylation was achieved.

Oxacycle synthesis via intramolecular reaction of carbanions and peroxides

The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

2-(1H-indolylsulfanyl)-aryl amine derivatives

The present invention relates to compounds of formula IV and their use.

Benzo[b]furane and benzo[b]thiophene derivatives

The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use.

Aryl Radical Endo Cyclization of Enamidines. Selective Preparation of Trans and Cis Fused Octahydrobenzo[f]quinolines

Aryl radicals from N-protected 6-[2-(2-halophenyl)ethyl]-1,2,3,4-tetrahydropyridines and 6-[3-(2-halophenyl)propyl]-1,2,3,4-tetrahydropyridines undergo intramolecular cyclization onto the enamide/ enamidine double bond by 6-endo and 7-endo closure, respectively. In the 6-endo cyclization the trans/cis ratio of the formed N-protected octahydrobenzo[f]quinoline can be controlled, and selective synthesis of either the trans or the cis isomer can be achieved with triphenyltin hydride and tris(trimethylsilyl)silicon hydride, respectively. In the 7-endo cyclization to N-protected octahydro-1H-benzo[3,4]cyclohepta[1,2-b]pyridine, the trans fused isomer predominates, although the selectivity is low. The oxidized cyclization products, with a restored enamide/enamidine double bond, are formed at low concentrations of tris(trimethylsilyl)silicon hydride.

Intramolecular palladium-catalyzed aryl amination and aryl amidation

Upon treatment with a palladium catalyst and a suitable base, aromatic halides undergo intramolecular substitution to form five, six, and seven-membered rings. In a similar fashion aryl halides with pendant amides or sulfonamides are cyclized to form five and six-membered rings.

Palladium catalyzed synthesis of annelated indoles

The synthesis of polycyclic indoles is shown to be accomplished readily by the palladium catalyzed intramolecular cyclization of bromoaryl bearing indoles.