178909-00-7Relevant academic research and scientific papers
DNA cleavage of novel propargylic sulfones. Enhancement of potency via intercalating interaction
Dai, Wei-Min,Fong, Kin Chiu,Danjo, Hiroshi,Nishimoto, Sei-Ichi,Solow, Michael,Mak, Wing Leung,Yeung, Mau Lam
, p. 1093 - 1098 (1996)
A number of novel hydroxy propargylic sulfones 7-15 were synthesized as DNA cleaving agents. Enhancement of DNA cleavage potency was observed with those compounds which could interact with DNA through intercalation of the extended aromatic rings.
Reduction of propargylic sulfones to (Z)-allylic sulfones using zinc and ammonium chloride
Sheldrake, Helen M.,Wallace, Timothy W.
, p. 4407 - 4411 (2008/02/03)
Propargylic sulfones can be cis-hydrogenated using commercial zinc powder and ammonium chloride in THF-water at room temperature, the major products being the corresponding (Z)-allylic sulfones. Other reducible groups (alkene, benzyloxy) are not affected. Allenylsulfones are implicated in one of the possible reaction pathways.
