DNA cleavage of novel propargylic sulfones. Enhancement of potency via intercalating interaction

DOI: 10.1016/0960-894X(96)00177-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1093 - 1098 (1996)

Update date:2022-08-03

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Authors:

Dai, Wei-Min

Fong, Kin Chiu

Danjo, Hiroshi

Nishimoto, Sei-Ichi

Solow, Michael

Mak, Wing Leung

Yeung, Mau Lam

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Article abstract of DOI:10.1016/0960-894X(96)00177-1

A number of novel hydroxy propargylic sulfones 7-15 were synthesized as DNA cleaving agents. Enhancement of DNA cleavage potency was observed with those compounds which could interact with DNA through intercalation of the extended aromatic rings.

Full text of DOI:10.1016/0960-894X(96)00177-1

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