178919-58-9Relevant academic research and scientific papers
Synthesis ans Biological Evaluation of Some New Fused Quinzoline Derivatives
Ibrahim, S. S.,Abdel-Halim, A. M.,Gabr, Y.,El-Edfawy, S.,Abdel-Rahman, R. M.
, p. 1041 - 1063 (2007/10/03)
Some new fused quinazoline derivatives have been prepared by reacting 3-N-acyl / aroylamino quinazolin-4(3)-ones (2) with different nucleophilic reagents.The structural assignments of all the new products were based on elemental analysis and chemical and spectroscopic data, and somw of the products have been screened for their antimicrobial activity. - Key Words: synthesis; biological; fused quinazolines
Quinazolinone derivatives: Synthesis and binding evaluation on cholecystokinin receptors
Varnavas,Lassiani,Luxich,Zacchigna,Boccu
, p. 333 - 339 (2007/10/03)
A series of 2-methyl-3-amino-4(H)-quinazolinone and of 2-phenyl-3-amino-4(H)-quinazolinone derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-B rather than CCK-A receptor and the obtained results confirm that the 4(3H)-quinazolinone nucleous represent a useful template for the development of selective CCK-B receptor ligands.
