178945-28-3

Basic information

• Product Name: 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
• Synonyms: 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
• CAS NO: 178945-28-3
• Molecular Weight: 547.61
• Mol File: 178945-28-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(178945-28-3)
• EPA Substance Registry System: 2,5-dihydro-3-[6-benzyloxy-1-(tert-butyloxycarbonyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione(178945-28-3)

Safety Data

• Hazardous Substances Data: 178945-28-3(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 174402-44-9 tert-butyl 6-(benzyloxy)-3-(4-bromo-1-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 174402-43-8 3-(6-benzyloxy-1H-indol-3-yl)-4-bromo-1-methyl-pyrrole-2,5-dione 

Downstream Products

• 188884-37-9 6-benzyloxy-3-{1-methyl-2,5-dioxo-4-[1-(3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-1H-indol-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}-indole-1-carboxylic acid tert-butyl ester 
• 188884-38-0 3-(6-Benzyloxy-1H-indol-3-yl)-1-methyl-4-[1-((2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-1H-indol-3-yl]-pyrrole-2,5-dione 
• 178945-30-7 2,5-dihydro-3-(6-benzyloxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 

Relevant articles and documents

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings

In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drag, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J- 107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404.