178945-30-7Relevant articles and documents
Practical synthesis of indolopyrrolocarbazoles
Ohkubo, Mitsuru,Nishimura, Teruyuki,Jona, Hideki,Honma, Teruki,Morishima, Hajime
, p. 8099 - 8112 (2007/10/03)
A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4- c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).