17903-36-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 21702-84-1 2,4-dibromoanisole 
• 17876-90-3 3-trimethylsilylanisol 
• 2398-37-0 3-methoxyphenyl bromide 

Downstream Products

• 1374337-13-9 C₂₃H₂₂OSi 

Relevant academic research and scientific papers

Palladium-catalyzed intermolecular coupling of 2-silylaryl bromides with alkynes: Synthesis of benzosiloles and heteroarene-fused siloles by catalytic cleavage of the C(sp3)-Si bond

Unusual split: A wide variety of benzosiloles and derivatives are obtained by the Pd-catalyzed intermolecular coupling of 2-silylaryl bromides and alkynes and the accompanying selective cleavage of the C(sp3)-Si bonds as a key step (see scheme). The product spectrum includes benzosiloles, benzothiophene-fused siloles, ladder-type π-conjugated benzosiloles, and thiophene-bridged 2,5-bisbenzosiloles.

ACETYLCHOLINESTERASE INHIBITORS

This invention relates to silylated aromatic fluoroketones possessing acetylcholinesterase-inhibiting properties and to their use in the treatment of Alzheimer disease and senile dementia