179076-05-2Relevant articles and documents
Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity
Sedrani, Richard,Jones, Lyn H.,Jutzi-Eme, Anne-Marie,Schuler, Walter,Cottens, Sylvain
, p. 459 - 462 (1999)
The cyclohexyl-subunit of rapamycin was cleaved by a sequence involving a Baeyer-Villiger reaction and acid hydrolysis of the resulting lactone- acetal as key steps. Binding of this new rapamycin derivative to FKBP12 was only slightly reduced by this modi