Bioorganic and Medicinal Chemistry Letters p. 459 - 462 (1999)
Update date:2022-08-04
Topics:
Sedrani, Richard
Jones, Lyn H.
Jutzi-Eme, Anne-Marie
Schuler, Walter
Cottens, Sylvain
The cyclohexyl-subunit of rapamycin was cleaved by a sequence involving a Baeyer-Villiger reaction and acid hydrolysis of the resulting lactone- acetal as key steps. Binding of this new rapamycin derivative to FKBP12 was only slightly reduced by this modi
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(1969)
