1791-13-5

Basic information

• Product Name: H-ASP(OTBU)-OTBU HCL
• Synonyms: L-ASPARTIC ACID DI-T-BUTYL ESTERHYDROCHL ORIDE CRYS;L-ASPARTIC ACID-1,4-DI-TERT-BUTYL ESTER HYDROCHLORIDE;H-Asp(Obut)-Obut hydrochloride;L-Aspartic acid, bis(1,1-dimethylethyl) ester, hydrochloride;H-Asp(OtBu)-OtBu•H-L-Asp(tBu)-OtBu*HCl;L-ASPARTIC ACID A, B-DI T-BUTYLESTER HYDROCHLORIDE;H-Asp(Obut)-Otbu HCl
• CAS NO: 1791-13-5
• Molecular Formula: C₁₂H₂₃NO₄*ClH
• Molecular Weight: 281.78
• EINECS: 274-664-7
• Product Categories: Amino Acids Derivatives;Amino Acids;Aspartic acid [Asp, D];Amino Acids and Derivatives;Amino Acid Derivatives;A - H;Amino Acids;Modified Amino Acids
• Mol File: 1791-13-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 152-155 °C
• Boiling Point: 339.8 °C at 760 mmHg
• Flash Point: 159.3 °C
• Appearance: /Solid
• Vapor Pressure: 6.39E-05mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: soluble in Methanol
• BRN: 5652807
• CAS DataBase Reference: H-ASP(OTBU)-OTBU HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP(OTBU)-OTBU HCL(1791-13-5)
• EPA Substance Registry System: H-ASP(OTBU)-OTBU HCL(1791-13-5)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 1791-13-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester.

Biochem/physiol Actions

L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester (G7501).

InChI:InChI=1/C12H23NO4.ClH/c1-11(2,3)16-9(14)7-8(13)10(15)17-12(4,5)6;/h8H,7,13H2,1-6H3;1H/t8-;/m0./s1

Upstream product

• 42417-76-5 1,4-di-tert-butyl (2S)-2-{[(benzyloxy)carbonyl]amino}butanedioate 
• 540-88-5 acetic acid tert-butyl ester 
• 13795-73-8 L-aspartic acid di-tert-butyl ester 

Downstream Products

• 103777-98-6 N-(N-Benzyloxycarbonyl-L-γ-glutamyl-1-tert.-butylester)-L-asparaginsaeure-di-tert.-butylester 
• 3057-74-7 L-Asp(t-Bu) 
• 87085-11-8 H-Tyr-Asp-OH 
• 250789-98-1 C₂₃H₃₃N₃O₇ 
• 1134634-58-4 di-tert-butyl (2S)-2-[(3-{[5-oxido-4-(phenylsulphonyl)-1,2,5-oxadiazol-3-yl]-oxy}-propionyl)-amino]-succinate 
• 438246-17-4 C₁₉H₂₆N₂O₈ 
• 280777-76-6 L-N-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetyl]aspartic acid 
• 1262887-73-9 (2S,2'S)-tetra-tert-butyl 2,2'-((5-nitroisophthaloyl)bis(azanediyl))disuccinate 
• 1262887-75-1 (2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate 
• 1262887-74-0 (2S,2'S)-tetra-tert-butyl 2,2'-((5-aminoisophthaloyl)bis(azanediyl))disuccinate 
• 1432474-25-3 C₃₅H₄₁NO₁₇ 

Relevant articles and documents

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was conjugated in three part constructs to RGD sequences and NO releasing heterocycles. In general the analogues showed integrin binding affinity comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines.