179162-55-1

Basic information

• Product Name: 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid
• Synonyms: 4-[5-[4-(Pentyloxy)phenyl]-3-isoxazolyl]benzoic acid;4-(5-{4-[(Pent-1-yl)oxy]phenyl}isoxazol-3-yl)benzoicacid;Micafungin Impurity 3;Micafungin Intermediate 2;4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid;4-(5-(4-(Pentyloxy)phenyl)isoxazol-3-yl)benzoic acid Micafungin InterMediate;4-[5-(4-Pentyloxy-phenyl)-isoxazol-2-yl]-benzoic acid
• CAS NO: 179162-55-1
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.39574
• Product Categories: Micafungin sodium
• Mol File: 179162-55-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 555.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.176±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone (Slightly, Heated), DMSO (Slightly)
• PKA: 3.72±0.10(Predicted)
• CAS DataBase Reference: 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid(179162-55-1)
• EPA Substance Registry System: 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoic acid(179162-55-1)

Safety Data

• Hazardous Substances Data: 179162-55-1(Hazardous Substances Data)

Usage

Uses

4-[5-(4-Pentyloxyphenyl)isoxazol-3-yl]benzoic Acidis used to optimize the side chain of the natural product FR901379.

Upstream product

• 628-17-1 amyl iodide 
• 99-96-7 4-hydroxy-benzoic acid 
• 543-59-9 1-Chloropentane 
• 1571-08-0 methyl 4-formylbenzoate 
• 5736-91-4 4-(n-pentyloxy)benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 5467-56-1 4-pentyloxyacetophenone 
• 110-53-2 1-Bromopentane 
• 99-93-4 4-Hydroxyacetophenone 
• 1431323-57-7 C₁₃H₁₆ClNO₃ 
• 1679-64-7 Monomethyl terephthalate 
• 50690-62-5 4-pentyloxyphenylacetophenone 
• 101023-70-5 4-methoxycarbonylbenzhydroxamic acid chloride 
• 79887-16-4 1-ethynyl-4-(pentyloxy)benzene 

Downstream Products

• 179163-95-2 Methyl 4-[5-(4-hexyloxyphenyl)-1H-pyrazol-3-yl]benzoate 
• 235114-32-6 micafungin 
• 1426839-86-2 C₂₇H₂₈N₃O₉P 
• 310459-15-5 PPIB-PFP 
• 1426839-82-8 PPIB-OSU 
• 1426839-89-5 C₂₁H₂₀ClNO₃ 
• 1426839-93-1 PPIB-MMTDA 
• 1426839-84-0 PPIB-MBT 
• 1426839-83-9 PPIB-OPHT 
• 1426839-88-4 C₂₆H₂₉NO₅ 
• 1426839-87-3 C₂₆H₂₉NO₆ 
• 235112-66-0 1-[[4-[5-(4-pentyloxyphenyl)isoxazol-3-yl]benzoyl]oxy]-1H-1,2,3-benzotriazole 

Relevant articles and documents

FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activity [1]

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Preparation method of high-purity micafungin intermediate

The invention belongs to the field of drug synthesis, relates to a preparation method of a high-purity micafungin intermediate, and concretely relates to a preparation method of a micafungin intermediate compound represented by formula A-4. The synthesis method is simple to operate and high in yield, and can meet the requirements of industrial production.

A concise synthesis of isoxazole-based side chain of Micafungin

A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and alkyne intermediates.

Lipopeptide Compounds and Their Use

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.