179238-80-3

Basic information

• Product Name: (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-2-phenyl-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol
• Synonyms: (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-2-phenyl-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol
• CAS NO: 179238-80-3
• Molecular Weight: 354.516
• Mol File: 179238-80-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-2-phenyl-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-2-phenyl-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol(179238-80-3)
• EPA Substance Registry System: (1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-2-phenyl-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol(179238-80-3)

Safety Data

• Hazardous Substances Data: 179238-80-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 176896-76-7 (1S,2S,5S)-2-hydroxy-3-(thiazol-2-ylmethylimino)pinane 

Downstream Products

• 144775-04-2 Boc-(R)-dolaphenine 
• 77119-85-8 N-(tert-butoxycarbonyl)-D-phenylalaninal 
• 144774-97-0 [R-(-)-2-phenyl-1-(2-thiazolyl)ethylamine] 

Relevant articles and documents

Alkylation of camphor and pinanone imines of 2-(aminomethyl)thiazole. Enantioselective synthesis of 2-(1-aminoalkyl)thiazoles

A method is described for the enantioselective synthesis of 2-(1-aminoalkyl)thiazoles 6 via stereoselective alkylation of the carbanions of (+)-(R)-camphor and (-)-(1S, 2S, 5S)-2-hydroxypinan-3-one imines 2 and 3 derived from 2-(aminomethyl)thiazole (2-AMT, 1). Compounds 6 serve as α-amino aldehyde precursors via thiazolyl-to-formyl conversion.