179343-23-8

Basic information

• Product Name: 6-(2,6-dibroMophenyl)pyrido[2,3-d]pyriMidine-2,7-diaMine
• Synonyms: 6-(2,6-dibroMophenyl)pyrido[2,3-d]pyriMidine-2,7-diaMine
• CAS NO: 179343-23-8
• Molecular Formula: C₁₃H₉Br₂N₅
• Molecular Weight: 395.05206
• Mol File: 179343-23-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-(2,6-dibroMophenyl)pyrido[2,3-d]pyriMidine-2,7-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,6-dibroMophenyl)pyrido[2,3-d]pyriMidine-2,7-diaMine(179343-23-8)
• EPA Substance Registry System: 6-(2,6-dibroMophenyl)pyrido[2,3-d]pyriMidine-2,7-diaMine(179343-23-8)

Safety Data

• Hazardous Substances Data: 179343-23-8(Hazardous Substances Data)

Usage

Uses

6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine has been found in 3D-QSAR studies to be a potential fibroblast growth factor receptor 1 inhibitor.

Upstream product

• 20781-06-0 2,4-diamino-5-pyrimidinecarboxaldehyde 
• 67197-53-9 2-(2,6-dibromophenyl)acetonitrile 

Downstream Products

• 179343-24-9 6-(2,6-dibromo-phenyl)-N²-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine 

Relevant articles and documents

Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase

A major challenge for new antibiotic discovery is predicting the physicochemical properties that enable small molecules to permeate Gram-negative bacterial membranes. We have applied physicochemical lessons from previous work to redesign and improve the antibacterial potency of pyridopyrimidine inhibitors of biotin carboxylase (BC) by up to 64-fold and 16-fold against Escherichia coli and Pseudomonas aeruginosa, respectively. Antibacterial and enzyme potency assessments in the presence of an outer membrane-permeabilizing agent or in efflux-compromised strains indicate that penetration and efflux properties of many redesigned BC inhibitors could be improved to various extents. Spontaneous resistance to the improved pyridopyrimidine inhibitors in P. aeruginosa occurs at very low frequencies between 10-8 and 10-9. However, resistant isolates had alarmingly high minimum inhibitory concentration shifts (16- to >128-fold) compared to the parent strain. Whole-genome sequencing of resistant isolates revealed that either BC target mutations or efflux pump overexpression can lead to the development of high-level resistance.

6-ARYL PYRIDO[2,3-D] PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION

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