67197-53-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,6-dibromophenyl)acetonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties. Its unique structure allows for the creation of molecules that can target specific biological pathways or receptors, leading to more effective treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(2,6-dibromophenyl)acetonitrile is utilized as a precursor in the production of pesticides and other crop protection agents. Its reactivity and structural features enable the design of compounds that can effectively control pests and diseases, thereby enhancing crop yields and quality.
Used in Organic Synthesis:
2-(2,6-dibromophenyl)acetonitrile is employed as a versatile intermediate in organic synthesis for the preparation of a wide range of organic compounds. Its bromine atoms facilitate various synthetic transformations, making it a useful component in the creation of complex organic molecules for research and industrial applications.
Safety Considerations:
It is crucial to handle 2-(2,6-dibromophenyl)acetonitrile with care due to its potential to cause irritation to the skin, eyes, and respiratory system. It should only be used by trained professionals in a controlled laboratory environment to ensure safety and minimize health risks.

InChI:InChI=1/C8H5Br2N/c9-7-2-1-3-8(10)6(7)4-5-11/h1-3H,4H2

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 69321-60-4 2,6-dibromotoluene 
• 1013031-65-6 (2,6-dibromophenyl)methanol 
• 93701-32-7 2,6-dibromobenzyl bromide 
• 858006-31-2 1,3-dibromo-2-(chloromethyl)benzene 
• 67713-23-9 2,6-dibromobenzaldehyde 
• 151-50-8 potassium cyanide 
• 76587-27-4 (2,6-Dibromo-phenyl)-acetaldehyde oxime 

Downstream Products

• 76574-83-9 6-(2,6-dibromophenyl)-2-methylpyrido[2,3-d]-pyrimidin-7-amine 
• 179343-23-8 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine 
• 901310-02-9 2-(2,6-dibromophenyl)acetic acid 
• 1047997-38-5 C₁₂H₁₃Br₂N 
• 179343-24-9 6-(2,6-dibromo-phenyl)-N²-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine 
• 851756-66-6 6-(2,6-dibromo-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one 
• 901310-01-8 N-methyl-2,6-dibromophenylacetamide 

Relevant academic research and scientific papers

An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (h

KRAS G12C INHIBITORS

The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.

Substituted benzocarbocycles by palladium-catalyzed cascade reactions featuring a C(sp3) - H activation step

Valuable 4- and 5-membered benzocarbocycles were synthesized via selective palladium-catalyzed cascade reactions which combined C(sp3)-H activation, Heck cyclization, Heck arylation or olefin hydrogenation. In all cases, all mechanistically independent steps were catalyzed by a single multi-functional catalyst.

Antihypertensive Activity of 6-Arylpyridopyrimidin-7-amine Derivatives

A series of 51 6-arylpyridopyrimidin-7-amine derivatives was prepared and evaluated for antihypertensive activity in the conscious spontaneously hypertensive rat.A number of these compounds, notably 6-(2,6-dichlorophenyl)-2-methylpyridopyrimidin-7-amine (36), lowered blood pressure in these rats in a gradual and sustained manner to normotensive levels at oral doses of 10-50 mg/kg.Normalized blood pressure levels could then be maintained by single daily oral doses.The effect of structural variation in the 6-aryl group and in the 2 and 4 positions of the pyridopyrimidine ring on activity is reported and discussed.