6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Base Information

• Chemical Name: 6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
• CAS No.: 179343-23-8
• Molecular Formula: C13H9Br2N5
• Molecular Weight: 395.05206
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60416143
• Nikkaji Number: J2.690.188J
• Wikidata: Q27097373
• Metabolomics Workbench ID: 151292
• ChEMBL ID: CHEMBL57531
• Mol file: 179343-23-8.mol

Synonyms:6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine;179343-23-8;Acetyl-CoA Carboxylase-IN-1;6-(2,6-dibromophenyl)pyrido-[2,3-d]pyrimidine-2,7-diamine;6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine;6-arylpyrido[2,3-d]pyrimidine deriv. 18;CHEMBL57531;ACS Chem. Biol. Compound 1;BDBM3436;SCHEMBL8124143;DTXSID60416143;2v58;HGIPWJYTPOHUGK-UHFFFAOYSA-N;Pyrido[2,3-d]pyrimidine-2,7-diamine, 6-(2,6-dibromophenyl)-;DB08144;MS-26645;HY-152117;CS-0635137;A881254;Q27097373;6-(2,6-dibromophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine;LZJ

Chemical Property of 6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property:

• PSA: 90.71000
• LogP: 4.54360
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 394.92042
• Heavy Atom Count: 20
• Complexity: 335

Purity/Quality:

97% ^*data from raw suppliers

6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)Br)C2=C(N=C3C(=C2)C=NC(=N3)N)N)Br
• Uses: 6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine has been found in 3D-QSAR studies to be a potential fibroblast growth factor receptor 1 inhibitor.

Technology Process of 6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

There total 1 articles about 6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0) + 2-(2,6-dibromophenyl)acetonitrile (67197-53-9) → 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (179343-23-8)

Guidance literature:

With sodium 2-ethoxyethoxide; for 4h; Heating;

DOI:10.1021/jm0004291

Reference yield: 61.0%

diethylaminopropylamine (104-78-9) + 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (179343-23-8) → 6-(2,6-dibromo-phenyl)-N2-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (179343-24-9)

Guidance literature:

With aminosulfonic acid; for 5h; Heating;

DOI:10.1021/jm0004291

Reference yield: 58.0%

6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (179343-23-8) + Tert-butyl isocyanate (1609-86-5) → 1-[2-Amino-6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

Guidance literature:

6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Tert-butyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Further stages.;

DOI:10.1021/jm0004291

upstream raw materials:

2,4-diamino-5-pyrimidinecarboxaldehyde

2-(2,6-dibromophenyl)acetonitrile

Downstream raw materials:

6-(2,6-dibromo-phenyl)-N²-(3-diethylamino-propyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

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