1794-47-4Relevant academic research and scientific papers
Mechanism of the Reduction of Ketones by Trialkylsilane. Hydride Transfer, SET-Hydrogen Atom Abstraction, or Free Radical Addition
Yang, D.,Tanner, D. D.
, p. 2267 - 2270 (1986)
The mechanism for the fluoride ion catalyzed reduction of ketones with phenyldimethylsilane was investigated.With reactive substrates (i.e., α,α,α-trifluoroacetophenone) the silane can act as a reducing agent to give, upon hydrolysis, moderate yields of the corresponding alcohol.The pentavalent anion formed from the silane and fluoride anion is, as had been previously reported, an excellent hydride reducing agent and even with moderate acceptors (i.e., α-fluoroacetophenone and cyclopropyl phenyl ketone) the anion acts as a SET reagent to give minor amounts of radical derived reduction products.
Light-Promoted Copper-Catalyzed Enantioselective Alkylation of Azoles
Li, Chen,Chen, Bin,Ma, Xiaodong,Mo, Xueling,Zhang, Guozhu
supporting information, p. 2130 - 2134 (2020/11/30)
A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C?H functionalization is reported. Under blue-light photoexcitation, a copper(I)/carbazole-based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.
Preparation method for p-phenylbutoxybenzoic acid
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Paragraph 0070-0071; 0078-0079, (2019/11/04)
The invention provides a preparation method for p-phenylbutoxybenzoic acid, belonging to the field of organic synthesis. According to the invention, palladium-based catalytic coupling is adopted, andthe Grignard reaction and the Friedel-Craft reaction are avoided, thereby avoiding the production of blue-green copper ion wastewater and generation of a large amount of acidic wastewater due to usageof aluminum trichloride; the preparation method of the invention is friendly to environment, simple in synthesis route and high in the yield of each step; and halogeno-benzene is used for replacing more expensive phenylmagnesium bromide and used as a starting material, so the preparation cost of p-phenylbutoxybenzoic acid is lowered. The p-phenylbutoxybenzoic acid obtained in the invention has good crystal form, high purity and good solubility. The data of embodiments of the invention show that the total yield of p-phenylbutoxybenzoic acid prepared in the invention is 60% or above, and the HPLC purity of p-phenylbutoxybenzoic acid is 99.9% or above.
Potassium Chlorochromate on a Solid Support: A Convenient and Mild Reagent for the Oxidation of Alcohols
Carlsen, Per H. J.,Husbyn, Mette,Braenden, Jon E,,Eliason, Robert
, p. 485 - 488 (2007/10/02)
The oxidation of primary and secondary alcohols by potassium chlorochromate supported on alumina or silica gel is reported.The results indicate that the yields in some cases depend on the support medium.Benzylic and secondary alcohols are oxidized in the best yields.The effect of solvent on the reaction is discussed and the conclusion is drawn that the best yields are obtained in non-polar solvents.
