179420-14-5

Basic information

• Product Name: 2H-Pyran-4-carboxamide, 4-[3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]phenyl]tetra hydro-
• CAS NO: 179420-14-5
• Molecular Formula: C23H24FN3O3
• Molecular Weight: 409.46
• Mol File: 179420-14-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-4-carboxamide, 4-[3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]phenyl]tetra hydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-4-carboxamide, 4-[3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]phenyl]tetra hydro-(179420-14-5)
• EPA Substance Registry System: 2H-Pyran-4-carboxamide, 4-[3-fluoro-5-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]phenyl]tetra hydro-(179420-14-5)

Safety Data

• Hazardous Substances Data: 179420-14-5(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 179420-13-4 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylic acid 
• 179421-07-9 4-cyano-4-(3,5-difluorophenyl)-3,4,5,6-tetrahydro-2H-pyran 
• 179420-11-2 ethyl 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate 
• 179420-66-7 ethyl 4-(5-benzyloxy-3-fluorophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate 
• 179420-67-8 ethyl 4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate 
• 763902-92-7 1-(4-Chloromethylphenyl)-2-methyl-1H-imidazole 
• 167758-58-9 4-(2-Methyl-1H-imidazol-1-yl)benzenemethanol 
• 122376-76-5 2-(3,5-difluorophenyl)acetonitrile 
• 130722-44-0 5-benzyloxy-3-fluorophenyl bromide 

Relevant articles and documents

4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5, 6-tetrahydro-2H-pyran-4-carboxamide, an Orally Active Inhibitor of 5-Lipoxygenase with Improved Pharmacokinetic and Toxicology Characteristics

Described herein are structure- activity relationships (SARs) of 4-[5-fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]-phenyl]-4-methoxy-3,4,5, 6-tetrahydro-2H-pyran (1, CJ-12,918), an imidazole 5-lipoxygenase (5-LO) inhibitor. When 1 was tested in precl

5-lipoxygenase inhibitors

Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: STR1 and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, py