17944-27-3

Upstream product

• 78830-79-2 (2,4-dichlorophenoxy)acetaldehyde diethyl acetal 
• 5441-16-7 1-(allyloxy)-2,4-dichlorobenzene 
• 1928-38-7 methyl 2,4-dichlorophenoxyacetate 
• 120-83-2 2,4-dichlorophenol 

Downstream Products

• 17592-43-7 4-(2,4-dichloro-phenoxy)-trans-crotonic acid 
• 63354-05-2 2-(2,4-dichlorophenoxymethyl)-1,3-oxathiolan-5-one 
• 115541-19-0 2-(2,4-dichlorophenoxymethyl)-4-(5'-nitro-2'-furyl)thiazole 
• 115541-26-9 2-(2,4-dichlorophenoxymethyl)-4-(1'-adamantyl)thiazole 
• 115540-98-2 2-(2,4-dichlorophenoxymethyl)-4-(2'-pyrazinyl)thiazole 
• 2302-32-1 2,4-dichlorophenoxythioacetamide 
• 3956-63-6 2-(2,4-dichlorophenoxy)acetonitrile 
• 2776-05-8 2,4-dichlorophenoxyacetaldoxime 
• 134671-29-7 2C₉H₁₀Cl₂N₄O₂*H₂O₄S 
• 65298-24-0 2-(2,4-dichloro-phenoxymethyl)-thiazolidin-4-one 
• 61756-77-2 (2,4-dichloro-phenoxy)-acetaldehyde-semicarbazone 

Relevant academic research and scientific papers

Catalyst-Free Decarbonylative Trifluoromethylthiolation Enabled by Electron Donor-Acceptor Complex Photoactivation

A catalyst- and additive-free decarbonylative trifluoromethylthiolation of aldehyde feedstocks has been developed. This operationally simple, scalable, and open-to-air transformation is driven by the selective photoexcitation of electron donor-acceptor (EDA) complexes, stemming from the association of 1,4-dihydropyridines (donor) with N-(trifluoromethylthio)phthalimide (acceptor), to trigger intermolecular single-electron transfer events under ambient- and visible light-promoted conditions. Extension to other electron acceptors enables the synthesis of thiocyanates and thioesters, as well as the difunctionalization of [1.1.1]propellane. The mechanistic intricacies of this photochemical paradigm are elucidated through a combination of experimental efforts and high-level quantum mechanical calculations [dispersion-corrected (U)DFT, DLPNO-CCSD(T), and TD-DFT]. This comprehensive study highlights the necessity for EDA complexation for efficient alkyl radical generation. Computation of subsequent ground state pathways reveals that SH2 addition of the alkyl radical to the intermediate radical EDA complex is extremely exergonic and results in a charge transfer event from the dihydropyridine donor to the N-(trifluoromethylthio)phthalimide acceptor of the EDA complex. Experimental and computational results further suggest that product formation also occurs via SH2 reaction of alkyl radicals with 1,2-bis(trifluoromethyl)disulfane, generated in-situ through combination of thiyl radicals. (Figure presented.).

ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B)

The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

Ozonolysis of Olefins VIII [1]. Synthesis of Phenoxyacetaldehydes by Ozonolysis of Allylphenylethers

A new route for the preparation of a series of phenoxyacetaldehydes (2a-j) which are useful intermediates or products, is described. It starts from the easily available allylphenylethers 1a-j which are ozonized at -40°C and further treated with dimethylsulfide to give solutions of the corresponding phenoxyacetaldehydes 2a-j; these are purified by column chromatography. Reaction of 2a-j with 1-methyl-1-phenylhydrazine leads to the corresponding hydrazones 3a-c, 3e-g, 3i, and 3j. The aldehydes can also be transformed into the stable dimethylcetals 4a, 4e, 4h, and 4i by reaction with trimethyl orthoformate.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives

A series of 5-substituted 3,5-dihydroxypentanoic acids and their derivatives have been prepared and tested for inhibition of HMG-CoA reductase in vitro. In general, unless a carboxylate anion can be formed and the hydroxy groups remain unsubstituted in an erythro relationship, inhibitory activity is greatly reduced. Furthermore, only one enantiomer of the ring-opened form of lactone 6a(±) possesses the activity displayed by the racemate. Insertion of a bridging unit other than ethyl or (E)-ethenyl between the 5-carbinol moiety and an appropriate lipophilic moiety (e.g., 2,4-dichlorophenyl) attenuates activity.