3956-63-6

Basic information

• Product Name: 2-(2,4-DICHLOROPHENOXY)ACETONITRILE
• Synonyms: 2,4-DICHLOROPHENOXYACETONITRILE;2-(2,4-DICHLOROPHENOXY)ACETONITRILE;BUTTPARK 96\57-60
• CAS NO: 3956-63-6
• Molecular Formula: C₈H₅Cl₂NO
• Molecular Weight: 202.04
• Mol File: 3956-63-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 46-48°C
• Boiling Point: 311.8°Cat760mmHg
• Flash Point: 142.4°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 0.000549mmHg at 25°C
• Refractive Index: 1.555
• BRN: 1958436
• CAS DataBase Reference: 2-(2,4-DICHLOROPHENOXY)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-DICHLOROPHENOXY)ACETONITRILE(3956-63-6)
• EPA Substance Registry System: 2-(2,4-DICHLOROPHENOXY)ACETONITRILE(3956-63-6)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S22:Do not inhale dust.; S36/37:Wear suitable protective clothing and gloves.
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 3956-63-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 14, p. 69, 1984 DOI: 10.1080/00397918408060866

InChI:InChI=1/C8H5Cl2NO/c9-6-1-2-8(7(10)5-6)12-4-3-11/h1-2,5H,4H2

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 590-17-0 cyanomethyl bromide 
• 17944-27-3 (2,4-dichlorophenoxy)acetaldehyde 
• 2776-05-8 2,4-dichlorophenoxyacetaldoxime 
• 107-14-2 chloroacetonitrile 
• 13543-09-4 2,4-dichlorophenoxymethyl chloride 
• 1982-42-9 2,4-dichlorophenoxyacetic acid amine 

Downstream Products

• 79295-15-1 2-(2,4-dichlorophenoxy)-N′-hydroxyacetimidamide 
• 115541-19-0 2-(2,4-dichlorophenoxymethyl)-4-(5'-nitro-2'-furyl)thiazole 
• 115541-26-9 2-(2,4-dichlorophenoxymethyl)-4-(1'-adamantyl)thiazole 
• 115540-98-2 2-(2,4-dichlorophenoxymethyl)-4-(2'-pyrazinyl)thiazole 
• 137988-11-5 Acetic acid 3-(2,4-dichloro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 137987-95-2 3-(2,4-Dichloro-phenoxy)-7-hydroxy-chromen-4-one 
• 98564-04-6 2,2,2-Trichlor-1,1-bis-<(2,4-dichlor-phenoxy)-acetamino>-ethan 
• 137987-83-8 2-(2,4-Dichloro-phenoxy)-1-(2,4-dihydroxy-phenyl)-ethanone 
• 2302-32-1 2,4-dichlorophenoxythioacetamide 
• 117889-48-2 5-(2,4-dichloro-phenoxymethyl)-1H-tetrazole 
• 94-75-7 2,4-Dichlorophenoxyacetic acid 

Relevant articles and documents

Development of oxadiazole-based ODZ10117 as a small-molecule inhibitor of STAT3 for targeted cancer therapy

Persistently activated STAT3 is a promising target for a new class of anticancer drug development and cancer therapy, as it is associated with tumor initiation, progression, malignancy, drug resistance, cancer stem cell properties, and recurrence. Here, we discovered 3-(2,4-dichloro-phenoxymethyl)-5-trichloromethyl-[1,2,4]oxadiazole (ODZ10117) as a small-molecule inhibitor of STAT3 to be used in STAT3-targeted cancer therapy. ODZ10117 targeted the SH2 domain of STAT3 regardless of other STAT family proteins and upstream regulators of STAT3, leading to inhibition of the tyrosine phosphorylation, dimerization, nuclear translocation, and transcriptional activity of STAT3. The inhibitory effect of ODZ10117 on STAT3 was stronger than the known STAT3 inhibitors such as S3I-201, STA-21, and nifuroxazide. ODZ10117 suppressed the migration and invasion, induced apoptosis, reduced tumor growth and lung metastasis, and extended the survival rate in both in vitro and in vivo models of breast cancer. Overall, we demonstrated that ODZ10117 is a novel STAT3 inhibitor and may be a promising agent for the development of anticancer drugs.

Skin whitening composition and use thereof

The present invention relates to a composition for skin whitening and a use thereof, does not cause cytotoxicity, and can provide a skin whitening effect by suppressing the expression and activity of an enzyme and a transcription factor which induce the production of melanin.

Synthesis and Antitubercular Activity of 4-(5-Nitro-2-furyl/2-pyrazinyl/1-adamantyl)-2-(alkyl/aryl/arylamino)thiazoles

The reaction of haloketones, obtained from Arndt-Eistert reaction on the acid chlorides of 1-adamantane, 5-nitrofuroic acid and pyrazine-2-carboxylic acid, with different thioamides and thioureas affords the title thiazoles (I-III).Some of them exhibit interesting antitubercular activity at 6.25 to 0.38 μg/ml concentration against H37Rv strain of M. tubercolosis in vitro testing.The structure activity relationship (SAR) has also been discussed.