179535-12-7

Upstream product

• 90763-47-6 4-Chloro-2-methoxy-5-nitro-benzoyl chloride 
• 179534-93-1 1-ethylazepan-3-amine 
• 68255-77-6 2-methoxy-4-chloro-5-nitrobenzoic acid 

Downstream Products

• 213627-52-2 N-(1-Ethyl-azepan-3-yl)-2-methoxy-5-nitro-4-propylamino-benzamide 
• 213627-51-1 4-Ethylamino-N-(1-ethyl-azepan-3-yl)-2-methoxy-5-nitro-benzamide 
• 213627-53-3 N-(1-Ethyl-azepan-3-yl)-4-isopropylamino-2-methoxy-5-nitro-benzamide 
• 179535-17-2 N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxy-4-methylamino-5-nitrobenzamide 
• 179535-18-3 5-amino-N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxy-4-methylaminobenzamide 
• 204759-11-5 5-Amino-4-ethylamino-N-(1-ethyl-azepan-3-yl)-2-methoxy-benzamide 
• 204759-13-7 5-amino-4-benzylamino-N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxybenzamide 
• 179535-22-9 4-benzylamino-N-(1-ethyl-1H-hexahydroazepin-3-yl)-2-methoxy-5-nitrobenzamide 

Relevant academic research and scientific papers

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities

A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with a medium perhydroazacycle ring in the amine moiety were prepared, and their antiemetic and gastroprokinetic activities were evaluated. Among them, N-(1-ethylhexahydroazepin-3-yl)-, N-(1-ethyloctahydroazocin-3-yl)- and N-(1- ethyloctahydroazonin-3-yl)-6-methoxy-1H-benzotriazole-5-carboxamides (24, 36, 37) showed a potent antiemetic activity (inhibition of apomorphine-induced emesis in dogs) along with gastroprokinetic activity (gastric emptying in rats).