179535-35-4

Upstream product

• 17929-90-7 3-aminoazepan-2-one 
• 76-83-5 trityl chloride 
• 75-03-6 ethyl iodide 
• 179534-94-2 (R)-α-triphenylmethylamino-ε-caprolactam 

Downstream Products

• 179535-36-5 1-ethyl-3-triphenylmethylamino-1H-hexahydroazepine 

Relevant academic research and scientific papers

6-methoxy-1H-benzotriazole-5-carboxamide derivatives and pharmaceutical compositions containing them

6-Methoxy-1H-benzotriazole-5-carboxamide derivatives which are represented by the formula (I) below: STR1 ?in which R1 stands for ethyl or cyclopropylmethyl group, R2 stands for hydrogen atom, methyl or ethyl group, n is 1, 2 or 3, a

A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin-3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors

A novel series of benzamides with a hexahydro-1,4-diazepine or hexahydroazepine ring in the amine moiety were prepared, and their binding affinities for 5-HT3 and dopamine 4 receptors were evaluated. The R isomer of the 1-ethyl-4-methylhexahydro-1,4-diazepinylbenzamide (R)-22 had potent affinity for both receptors. The R-enantiomer of the corresponding 1-ethylhexahydroazepinylbenzamide 28 showed potent affinity for dopamine D2 receptors with reduced affinity for 5-HT3 receptors, while the S isomer was found to be a potent and selective 5-HT3 receptor antagonist.