179618-34-9

Upstream product

• 611-71-2 (R)-Mandelic Acid 
• 124876-74-0 Methyl (R)-(-)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate 
• 179618-33-8 ethyl (2E,4S)-4-{[(tert-butyl)(dimethyl)silyl]oxy}-4-phenylbut-2-enoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 20698-91-3 (R)-methyl mandelate 
• 153293-97-1 ethyl (R)-2-(tert-butyldimethylsilyloxy)-2-phenylacetate 
• 130115-07-0 (R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde 

Downstream Products

• 187931-99-3 ethyl (4S,5S)-5-[(R)-{[(tert-butyl)(dimethyl)silyl]oxy}(phenyl)methyl]-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 246035-59-6 (4S,6R)-6-[(1R,2R)-1,2-dihydroxy-2-phenylethyl]-4-hydroxy-tetrahydro-2H-2-pyranone 
• 338385-70-9 (4S,5S)-5-[(R)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 1256338-97-2 2-{(4R,5S)-5-[(R)-{[(tert-butyl)(dimethyl)silyl]oxy}(phenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}ethanol 
• 185335-97-1 Toluene-4-sulfonic acid (2R,3S,4R)-4-(tert-butyl-dimethyl-silanyloxy)-2,3-dihydroxy-4-phenyl-butyl ester 
• 252273-59-9 (R)-2-Benzenesulfonyl-1-{(4R,5S)-5-[(S)-(tert-butyl-diphenyl-silanyloxy)-phenyl-methyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-4,4,4-trimethoxy-butan-1-ol 
• 252273-62-4 (2R,3S,4S)-1-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenyl-1-trifluoromethanesulfonyloxybutane 
• 252273-61-3 (1S,2S,3R)-1-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-1-phenylbutan-4-ol 
• 214678-53-2 (2R,3S,4R)-1-(t-butyldimethylsilyloxy)-2,3-isopropylidenedioxy-4-phenyl-1-trifluoromethanesulfonyloxybutane 
• 214678-61-2 (R)-4-Benzenesulfonyl-6-((1R,2S)-1,2-dihydroxy-2-phenyl-ethyl)-tetrahydro-pyran-2-one 
• 214678-52-1 {(4R,5S)-5-[(R)-{[(tert-butyl)(dimethyl)silyl]oxy}(phenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methanol 

Relevant academic research and scientific papers

Concise total synthesis of (+)-goniofufurone and goniobutenolides A and B

Cytotoxic styryl lactones, (+)-goniofufurone and goniobutenolides A and B have been prepared in optically and diastereometically pure form from (R)-(- )-mandelic acid via the β-hydroxy sulfone 4 as a common intermediate.

Concise stereoselective total synthesis of leiocarpin C

A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO4-catalyzed cis-hydroxylation and selective reduction with K-Selectride as key steps. Copyright

Easy access to an enantiopure precursor of (+)-goniodiol

Asymmetric synthesis of the epoxide 2 has been achieved from (R)-mandelic acid 3 via highly diastereoselective Wittig reaction and erythro-selective OsO4 catalyzed cis-hydroxylation as key steps. Copyright (C) Elsevier Science Ltd.