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39620-02-5

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39620-02-5 Usage

Uses

5-Bromonicotinoyl Chloride is a building block that has been used as a reactant for the preparation of fosmidomycin analogs as an antimalarial compound with DXR inhibition activity and the preparation of cupsin 1, an upregulator of survival motor neuron (SMN) protein-1.

Check Digit Verification of cas no

The CAS Registry Mumber 39620-02-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,6,2 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 39620-02:
(7*3)+(6*9)+(5*6)+(4*2)+(3*0)+(2*0)+(1*2)=115
115 % 10 = 5
So 39620-02-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClNO/c7-5-1-4(6(8)10)2-9-3-5/h1-3H

39620-02-5 Well-known Company Product Price

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  • Alfa Aesar

  • (L15510)  5-Bromonicotinoyl chloride, 98%   

  • 39620-02-5

  • 5g

  • 702.0CNY

  • Detail
  • Alfa Aesar

  • (L15510)  5-Bromonicotinoyl chloride, 98%   

  • 39620-02-5

  • 25g

  • 2342.0CNY

  • Detail

39620-02-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromopyridine-3-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 5-bromo-3-pyridinecarbonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:39620-02-5 SDS

39620-02-5Relevant articles and documents

Developing dual functional allosteric modulators of GABAA receptors

Liu, Xiaodong F.,Chang, Hui-Fang,Schmiesing, Richard Jon,Wesolowski, Steven S.,Knappenberger, Katharine S.,Arriza, Jeffrey L.,Chapdelaine, Marc J.

, p. 8374 - 8382 (2010)

Positive modulators at benzodiazepine sites of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Negative allosteric modulators of α5-containing GABAA receptors enhance cognition. By oocyte two-electrode voltage clamp and subsequent structure-activity relationship studies, we discovered cinnoline and quinoline derivatives that were both positive modulators at α2-/α3-containing GABAA receptors and negative modulators at α5-containing GABAA receptors. In addition, these compounds showed no functional activity at α1-containing GABAA receptors. Such dual functional modulators of GABAA receptors might be useful for treating comorbidity of anxiety and cognitive impairments in neurological and psychiatric illnesses.

From ergolines to indoles: Improved inhibitors of the human H3 receptor for the treatment of narcolepsy

Auberson, Yves P.,Troxler, Thomas,Zhang, Xuechun,Yang, Charles R.,Feuerbach, Dominik,Liu, Yu-Chih,Lagu, Bharat,Perrone, Mark,Lei, Lijun,Shen, Xiaoxia,Zhang, Dushan,Wang, Chunxiu,Wang, Tie-Lin,Briner, Karin,Bock, Mark G.

, p. 266 - 275 (2015)

Ergolines were recently identified as a novel class of H3 receptor (H3R) inverse agonists. Although their optimization led to drug candidates with encouraging properties for the treatment of narcolepsy, brain penetration remained low. To overcome this issue, ergoline 1 ((6aR,9R,10aR)-4-(2-(dimethylamino)ethyl)-N-phenyl-9-(pyrrolidine-1-carbonyl)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7(4H)-carboxamide)) was transformed into a series of indole derivatives with high H3R affinity. These new molecules were profiled by simultaneous determination of their brain receptor occupancy (RO) levels and pharmacodynamic (PD) effects in mice. These efforts culminated in the discovery of 15m ((R)-1-isopropyl-5-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-1H-indol-4-yl)pyridin-2(1H)-one), which has an ideal profile showing a strong correlation of PD effects with RO, and no measurable safety liabilities. Its desirably short duration of action was confirmed by electroencephalography (EEG) measurements in rats.

Phenylpyridine compound and preparation and application thereof

-

Paragraph 0074-0076, (2021/03/13)

The invention discloses a phenylpyridine compound and preparation and application thereof. The compound is used as a tumor multidrug resistance reversal agent and a chemotherapeutic drug sensitizer. Pharmacological experiment results show that the compound provided by the invention has excellent tumor multidrug resistance reversal activity and sensitization chemotherapy drug activity, and can be clinically used as a malignant tumor multidrug resistance reversal agent and a chemotherapy drug sensitizer.

Synthesis of N-trifluoromethyl amides from carboxylic acids

Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.

supporting information, p. 2245 - 2255 (2021/08/12)

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.

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