179686-77-2Relevant academic research and scientific papers
Enzymatic resolution of alicyclic 1,3-amino alcohols in organic media
Peter, Maria,Van Der Eycken, Johan,Bernath, Gabor,Fueloep, Ferenc
, p. 2339 - 2347 (1998)
Racemic cis- and trans-2-aminocyclohexane-1-methanol and cis- and trans- 2-amino-4-cyclohexene-1-methanol were resolved via lipase-catalysed O- acylation of their Z derivatives, using vinyl butyrate in different ether solvents. In accordance with the empi
Synthesis of Chiral Thiourea-Thioxanthone Hybrids
Mayr, Florian,Mohr, Lisa-Marie,Rodriguez, Elsa,Bach, Thorsten
, p. 5238 - 5250 (2017/10/30)
Four different 1-aminocyclohexanes bearing a tethered thioxanthone group in the 2-position were prepared. The synthesis commenced with the respective N-protected β-amino acids, the carboxyl group of which was employed for the introduction of the thioxanthone moiety. After construction of the thioxanthone and protecting group removal, the conversion of the amino group into the respective thiourea was accomplished by treatment with N -3,5-bis(trifluoromethyl)phenyl isothiocyanate and yielded the title compounds in which the thioxanthone resides in different spatial positions relative to the thiourea motif. Overall yields varied between 20-35%.
Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient
-
, (2008/06/13)
A benzene-fused heteroring derivative of formula (I) 1, wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is
