109087-15-2

Upstream product

• 61936-37-6 (+/-)-cis-2-formylamino-cyclohexanecarboxylic acid 
• 54867-08-2 cis-2-(benzyloxycarbonylamino)cyclohexanecarboxylic acid 
• 77612-29-4 cis-2-ethyloxycarbonylamino-1-cyclohexanecarboxylic acid 
• 72450-81-8 cis-2-(4'-Chlorphenyl)-4,5-tetramethylen-4,5-dihydro-6H-1,3-oxazin 
• 5691-20-3 (1RS,2SR)-2-aminocyclohexanecarboxylic acid 
• 110-83-8 cyclohexene 
• 34102-49-3 7-azabicyclo<4.2.0>octan-8-one 

Downstream Products

• 119670-94-9 [(1S,2R)-2-(Adamantan-2-ylamino)-cyclohexyl]-methanol; hydrochloride 
• 119670-95-0 C₁₉H₃₀N₂O*Cl^(1-)*2H⁽¹⁺⁾ 
• 109086-84-2 (2S,4aR,8aS)-2-p-Tolyl-octahydro-benzo[d][1,3]oxazine 
• 109214-69-9 cis-2-(p-chlorophenyl)perhydro-3,1-benzoxazine 
• 81969-59-7 (r-4,c-2,c-5)-2-(p-nitrophenyl)-4,5-tetramethylenetetrahydro-1,3-oxazine 
• 109214-70-2 (2S,4aR,8aS)-2-Phenyl-octahydro-benzo[d][1,3]oxazine 
• 109086-85-3 (2S,4aR,8aS)-2-(4-Methoxy-phenyl)-octahydro-benzo[d][1,3]oxazine 
• 117993-28-9 2-{[(E)-(1S,2R)-2-Hydroxymethyl-cyclohexylimino]-methyl}-phenol 
• 119670-93-8 [(1S,2R)-2-(4-tert-Butyl-cyclohexylamino)-cyclohexyl]-methanol; hydrochloride 
• 137539-49-2 4-Bromo-2-(4aS,8aR)-octahydro-benzo[d][1,3]oxazin-2-yl-phenol 
• 213672-66-3 cis-(+/-)-benzyl[2-(hydroxymethyl)cyclohexyl]carbamate 

Relevant academic research and scientific papers

Synthesis of 1-[2-(hydroxymethyl)cyclohexyl]pyrimidine analogues of nucleosides: A comparative study

The synthesis of a new series of 1,2-disubstituted carbonucleosides analogues of pyrimidine (cyclohexane derivatives) is reported. For the synthesis of the uridine analogue 5a, either construction of the base on the amino group of the amino alcohol 3 or o

POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY

The present invention is to provide a novel compound (I), having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. Compound (I) wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.

1,2-Disubstituted cyclohexane carbocyclic analogues of nucleosides

Several compounds of a new series of cyclohexane-based 1,2-disubstituted carbonucleoside analogues, were synthesized. The adenine and uridine derivatives, were prepared by construction of the heterocyclic base on the primary amino group of 2-aminocyclohexylmethanol, and the thymine derivative by condensation of 2-hydroxycyclohexylmethanol with thymine using the Mitsunobu reaction.

The Mechanism of Electrochemical Reduction of Partially Saturated Bicyclic 2-Phenylsubstituted-1,3-oxazines

Partially saturated bicyclic 2-phenylsubstituted 1,3-oxazines of the type 1-6 are reduced in a 2e step at the azomethine bond by controlled potential electrolysis in acidic electrolytes.By ring-chain tautomerism, the resulting bicyclic tetrahydro-1,3-oxazines (2e products) form the corresponding ring-opened aldimine derivatives, which are reduced in a further 2e step to the corresponding amines (4e products), and which are also hydrolyzed to the aminoalcohols and aldehydes.This explains the poor yields of the 4e products.The behaviour of the bicyclic tetrahydro-1,3-oxazines was rationalized by comparisons with the authentic substances 7 and 8.

STEREOCHEMICAL STUDIES XXXVIII SATURATED HETEROCYCLES, XIV; SYNTHESIS AND CONFORMATIONAL ANALYSIS OF STEREOISOMERIC CIS- AND TRANS-TETRAMETHYLENETETRAHYDRO-N-METHYL- AND -N-BENZYL-1,3-OXAZINES

Cis and trans-2-methylaminomethyl- and -benzylaminomethyl-1-cyclohexanol (1-4), as well as cis- and trans-2-hydroxymethyl-1-methylamino- and -benzylamino-cyclohexane (5-8) were allowed to react with p-nitrobenzaldehyde to yield 2-p-nitrophenyl-3-methyl- a