213764-26-2

Upstream product

• 203064-42-0 N-[(1S,2R)-2-hydroxymethylcyclohexyl]benzamide 
• 116261-07-5 (1S,2R)-2-hydroxymethyl-1-cyclohexanecarboxamide 
• 71581-92-5 (1R,2S)-cis-N-benzyl-2-aminocyclohexanemethanol 

Downstream Products

• 203064-43-1 3-N-[(1S,2R)-2-(3-nicotinoyloxymethyl)cyclohexyl]carbamoylpyridine 
• 179686-77-2 tert-butyl [(1S,2R)-2-(hydroxymethyl)cyclohexyl]carbamate 
• 779353-34-3 C₁₉H₂₃BrN₆O₂ 
• 779353-04-7 C₂₁H₂₈N₆O₂ 
• 352356-37-7 tert-butyl [(1S,2R)-2-formylcyclohexyl]carbamate 
• 203064-44-2 3-N-[(1S,2R)-2-hydroxymethylcyclohexyl]carbamoylpyridine 

Relevant academic research and scientific papers

Chirality control by substituents in the asymmetric addition of Et2Zn to aromatic aldehydes catalyzed by cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid derived 1,3-aminoalcohols

A series of novel optically active 1,3-aminoalcohols based on cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid and trans-(1R,2R)-2-benzamidocyclohexanecarboxylic acid were synthesized and used in the asymmetric diethylzinc addition to aromatic aldehydes.

Pyrazolotriazines as kinase inhibitors

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Precursors for the production of chiral 1,3-aminoalcohols

The disclosure describes novel precursors for the preparation of chiral 1,3-aminoalcohols. The precursors are chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides produced from chiral gamma-lactones, which in turn are derived from 1,4-diols by stereoselective oxidation. The chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides are converted into chiral 1,3-aminoalcohols by stereospecific rearrangement.

Rational de novo design of NADH mimic for stereoselective reduction based on molecular orbital calculation

The methodology of rational design of NADH mimics in stereoselective reduction of carbonyl and imino groups based on molecular orbital calculation was described. The designed NADH mimics 1a and 1b were subjected to the reduction of benzoylformate and acetyliminophenylacetate. As expected from the calculations of the transition-states, the reduction with 1a proceeded with high stereoselectivity in both substrates, while 1b showed much lower chirality transfer.