1415310-22-3

Upstream product

• 1415310-20-1 (R)-5-(tert-butyldiphenylsilyloxy)-1-(p-tolylsulfinyl)pentan-2-one 
• 1415310-21-2 (S)-5-(tert-butyldiphenylsilyloxy)-1-((R)-p-tolylsulfinyl)pentan-2-ol 
• 100-39-0 benzyl bromide 
• 179690-96-1 methyl 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butanoate 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 

Downstream Products

• 1415310-33-6 (4S,5S)-5-(benzyloxy)-2-8-(tert-butyldiphenylsilyloxy)oct-1-en-4-ol 
• 1415310-89-2 (4R,5S)-5-(benzyloxy)-2-8-(tert-butyldiphenylsilyloxy)oct-1-en-4-ol 
• 1415310-36-9 C₃₇H₅₃BrO₃Si₂ 
• 1415310-39-2 (4S,5S)-5-(benzyloxy)-1-((4S,6S)-6-(but-3-en-1-yl)-2,2-dimethyl-1,3-dioxan-4-yl)-4-((tert-butyldimethylsilyl)oxy)-8-((tert-butyldiphenylsilyl)oxy)-2-methyleneoctan-1-one 
• 1006058-88-3 (S)-2-(benzyloxy)-5-(tert-butyldiphenylsilyloxy)pentanal 

Relevant academic research and scientific papers

Diastereoselective synthesis of the C17-C30 fragment of amphidinol 3

The diastereoselective synthesis of the C17-C30 fragment of amphidinol 3 (AM3) 1 was achieved from the enantio-enriched aldehyde 20, Weinreb amide 14 and 2-bromo-3-(trimethylsilyl)propene, which was used as a bifunctional conjunctive reagent. The absolute configuration of the stereogenic centers, in both aldehyde 20 and Weinreb amide 14, were efficiently controlled by using (+)-(R)-methyl-p-tolylsulfoxide as the unique source of chirality.