179762-64-2

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 
• 589-87-7 1,4-bromoiodobenzene 
• 22480-64-4 4-bromophenyllithium 

Downstream Products

• 936836-28-1 [6-allyl-6-(4-bromo-phenyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-tert-butyl-diphenyl-silane 
• 179762-60-8 N-{4-[(2S,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-phenyl}-2,2,2-trifluoro-acetamide 
• 179762-59-5 N-(4-{(2S,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-phenyl)-2,2,2-trifluoro-acetamide 
• 179762-57-3 N-{4-[(3aS,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-phenyl}-2,2,2-trifluoro-acetamide 
• 179762-56-2 5-O-t-Butyldiphenylsilyl-2,3-O-isopropylidene-1-deoxy-1-(p-aminophenyl)-β-D-ribofuranose 
• 183377-91-5 2,2,2-Trifluoro-N-[4-((3aS,4S,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-phenyl]-acetamide 
• 179762-58-4 1-Deoxy-1-[p-(N-TFA)aminophenyl]-β-D-ribofuranose 
• 881424-04-0 acetic acid 5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-6a-(4-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-hexahydro-furo[3,2-b]furan-3-yl ester 
• 881423-95-6 acetic acid 6a-(4-bromo-phenyl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]furan-3-yl ester 
• 881423-78-5 (1R,5S,7R,8R)-5-(4-bromophenyl)-7-[(tert-butyldiphenylsilyloxy)methyl]-2,6-dioxabicyclo[3.3.0]octane-3,8-diyl diacetate 
• 936835-57-3 (3aS,5R,6R,6aR)-3a-(4-Bromo-phenyl)-5-(tert-butyl-diphenyl-silanyloxymethyl)-hexahydro-furo[3,2-b]furan-2,6-diol 

Relevant academic research and scientific papers

Effects of halogenated WNA derivatives on sequence dependency for expansion of recognition sequences in non-natural-type triplexes

Triplex-forming oligonucleotides (TFOs) are sequence-specific DNA-binding agents, but their target duplexes are limited to homopurine/homopyrimidine sequences because of interruption of the pyrimidines bases in the purine region. This problem has not been

Modified Nucleosides for Ribozyme Structure-Activity Studies

C-Phenyl, C-p-aminophenyl and C-naphthyl as well as pyridine-4(2)-one ribofuranosides were synthesized and site-specifically incorporated into a hammerhead ribozyme using solid phase synthesis.The modified oligonucleotides were used to probe the structural requirements at position 7 for catalytic activity.A pyridine-4-one-base substitution at a single position (N7) within the ribozyme catalytic core increased catalytic rate 10-fold.C-Phenyl, N3-methyluracyl, and p-aminophenyl base substitution at N7 reproducibly increased the catalytic rate twofold.

Synthesis of 1-deoxy-1-C-(p-aniline)-β-D-ribofuranose and its incorporation into hammerhead ribozymes

p-AnilineC-ribofuranoside 11 was prepared in 5 steps from 1-bromo-4-lithiobenzene (1) and D-ribono-1,4 lactone 2. A three step derivatization of 11 yielded 3'-O-phosphoramidite 14 which was incorporated into ribozymes using the solid phase phosphoramidite procedure.