17989-06-9Relevant academic research and scientific papers
Double nucleophilic 1,2-addition of silylated dialkyl phosphites to 4-phosphono-1-aza-1,3-dienes: Synthesis of γ-phosphono-α- aminobisphosphonates
Masschelein, Kurt G. R.,Stevens, Christian V.
, p. 9248 - 9252 (2007)
(Chemical Equation Presented) γ-Phosphono-α- aminobisphosphonates were synthesized from a new class of 4-phosphono-1-aza-1,3- dienes by the addition of dialkyl trimethylsilyl phosphites to these azadienes in the presence of acid. Depending on the steric demand of the group on nitrogen, double 1,2-addition or tandem 1,4-1,2-addition occurred.
Alkyl phosphonate preparing method
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Paragraph 0088; 0089; 0090; 0091, (2017/10/07)
The invention provides an alkyl phosphonate preparing method. The method comprises: performing an Arbuzov reaction on compound A and compound B in a continuous reaction apparatus, and continuously discharging the product obtained from the reaction from the continuous reaction apparatus during the reaction procedure, to obtain alkyl phosphonate. The reaction temperature in the reaction procedure is T1; either of compound A and compound B having a lower boiling point has a boiling point at a standard atmosphere pressure to be T2; T1 is higher than T2 by 10-40 DEG C; and the reaction pressure in the reaction procedure is 0.5-2.0 MPa. The preparing method in the invention may use halohydrocarbon having large steric hindrance and lower polarizability of carbon-halogen bond as compound A, thereby effectively expanding a selection range of substrate, and correspondingly expanding the types of alkyl phosphonate prepared by using the Arbuzov reaction.
Polyethylene glycol-promoted dialkyl, aryl/heteroaryl phosphonates
Naidu, K. Reddi Mohan,Dadapeer, Naidu E.,Reddy, C. Bhupendra,Rao, A. Janardhan,Reddy, C. Suresh,Raju, C. Naga
experimental part, p. 3462 - 3468 (2011/09/16)
A new, straightforward polyethylene glycol-promoted method for Michaelis-Arbuzov rearrangement has been described.
Epoxydation catalitique de phosphonates α,β- et β,γ-ethyleniques a l'aide d'hydroperoxydes
Sturtz, Georges,Pondaven-Raphalen, Annick
, p. 125 - 130 (2007/10/02)
The α,β- and β,γ-unsaturated phosphonates can be epoxidized with two catalytic systems, hydrogen peroxide in the presence of sodium tungstate and t-butyl hydroperoxide in the presence of molybdenum hexacarbonyl.Whatever the conditions used, β,γ-unsaturated ones.The molybdenum/t-butyl hydroperoxide complex has been found to be the most effective epoxidising agent in the preparation of dialkyl 2,3-epoxy alkyl phosphonates.
