Double nucleophilic 1,2-addition of silylated dialkyl phosphites to 4-phosphono-1-aza-1,3-dienes: Synthesis of γ-phosphono-α- aminobisphosphonates

Article abstract of DOI:10.1021/jo701718t

(Chemical Equation Presented) γ-Phosphono-α- aminobisphosphonates were synthesized from a new class of 4-phosphono-1-aza-1,3- dienes by the addition of dialkyl trimethylsilyl phosphites to these azadienes in the presence of acid. Depending on the steric demand of the group on nitrogen, double 1,2-addition or tandem 1,4-1,2-addition occurred.