179894-26-9Relevant academic research and scientific papers
The development of a manufacturable synthesis of LY213829
Slattery, Brian J.,Kjell, Douglas P.,Copp, James D.,Ginah, Francis O.,Hansen, Marvin M.,Stirm, Stephen C.
, p. 295 - 297 (2013/09/07)
The development of a manufacturable synthesis of LY213829 (4-thiazolidinone-5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl] methyl) is described. Rather than reduction to eliminate the thiocarbonyl from the rhodanine moiety, the new route utilizes a novel
Product structure as a function of reaction conditions in the reaction of formaldehyde with an alpha-mercapto amide
Copp, James D.,Ginah, Francis O.,Hansen, Marvin M.,Kjell, Douglas P.,Slattery, Brian J.
, p. 1307 - 1312 (2007/10/03)
Treatment of mercapto amide (3) with formaldehyde and acid or base results in products whose structures are a function of the reaction conditions. Lactone (8), hemithioacetal (9), and dimer (7) were formed in good yields under acidic reaction conditions.
Synthesis of enantioenriched 4-thiazolidinone (-)-LY213829 by chemoselective benzylamide cleavage in the presence of a C-S bond
Hansen, Marvin M.,Harkness, Allen R.,Khau, Vien V.,Martinelli, Michael J.,Deeter, Jack B.
, p. 2515 - 2518 (2007/10/03)
(R)-2-Methylbenzylamine has been used to covalently 'resolve' thiol acid 7 and assemble 4-thiazolidinone 8a in one step. Selective deprotection of the 2-methylbenzylamide using lithium in ammonia/THF has been achieved in the presence of a readily hydrogen
Process for preparing benzyl-substituted rhodanine derivatives
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, (2008/06/13)
The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. The process is particularly useful for synthesizing the enantiomers of such derivatives. Also provided are novel benzyl-substituted mercaptopropanoic ac
