6214-64-8

Basic information

• Product Name: ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE
• Synonyms: ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE;Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate ,97%;ethyl 6-Methyl-2-oxo-1,2-dihydropyriMidine-5-carboxylate;Ethyl 6-Methyl-2-oxo-1,2-dihydro-5-pyriMidinecarboxylate;5-Pyrimidinecarboxylicacid, 1,2-dihydro-4-methyl-2-oxo-, ethyl ester;2-Hydroxy-4-methyl-pyrimidine-5-carboxylic acid ethyl ester
• CAS NO: 6214-64-8
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.18
• Product Categories: Building Blocks;Pyrimidine
• Mol File: 6214-64-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 250-252 °C
• Boiling Point: 563oC at 760 mmHg
• Flash Point: 294.3oC
• Appearance: /
• Density: 1.28g/cm3
• Vapor Pressure: 7.42E-06mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• PKA: 8.46±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE(6214-64-8)
• EPA Substance Registry System: ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE(6214-64-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 6214-64-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H10N2O3/c1-3-13-7(11)6-4-9-8(12)10-5(6)2/h4H,3H2,1-2H3,(H,9,10,12)

Upstream product

• 6319-01-3 ethyl 2-acetyl-3-ureido-2-propenoate 
• 17994-55-7 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 122-51-0 orthoformic acid triethyl ester 
• 57-13-6 urea 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 452357-80-1 ethyl 4-(trichloro-methyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Downstream Products

• 6214-65-9 5-acetyluracil 
• 5948-72-1 ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 17616-21-6 1,2-dihydro-6-methyl-2-oxo-5-(thiophene-2-carbonyl)pyrimidine 
• 227078-96-8 5-ethoxycarbonyl-6-methyl-4-butyl-3,4-dihydropyrimidin-2(1H)-one 
• 17994-57-9 5-ethoxycarbonyl-4-ethyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 13008-17-8 4-methyl-2-oxo-1H-pyrimidine-5-carboxylic acid 

Relevant articles and documents

RECYCLIZATION OF 5-CARBETHOXY-4-METHYL-2-MERCAPTO(AMINO, HYDROXY) PYRIMIDINES TO GIVE 5-ACETYL-2-MERCAPTO(AMINO, HYDROXY)-4-HYDROXYPYRIMIDINES

Conditions for the selective preparation of 5-carbethoxy-4-methyl-2-substituted pyrimidines or 5-acetyl-4-hydroxy-2-substituted pyrimidines by condensation of ethoxymethyleneacetoacetic ester with 1,3-binucleophiles are proposed.It is shown that under the influence of sodium ethoxide 5-carbethoxy-4-methyl-2-substituted pyrimidines undergo rearrangement to 5-acetyl-4-hydroxy-2-substituted pyrimidines.

Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of

Investigation on possibility of rearrangement of pyrimidine-5-carboxylic acids esters

A previously reported rearrangement of pyrimidine-5-carboxylic acids esters to 5-acylpyrimidones does not, in fact, occur in any of the examples studied by us.