18005-40-8

Usage

Uses

Precursor to chemical warfare agents.

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 148, 1959 DOI: 10.1021/ja01510a034

InChI:InChI=1/C3H9O2PS/c1-3-5-6(2,4)7/h3H2,1-2H3,(H,4,7)

Upstream product

• 5284-09-3 ethyl methylphosphonochloridate 
• 6996-81-2 O,O-diethyl methanephosphonothionate 
• 2524-16-5 O-ethyl methylchlorothiophosphonate 
• 676-97-1 methylphosphonic acid dichloroanhydride 
• 141-52-6 sodium ethanolate 

Downstream Products

• 2511-10-6 O,S-diethyl methylphosphonothionate 
• 65190-54-7 Methyl-phosphonothioic acid S-benzhydryl ester O-ethyl ester 

Relevant academic research and scientific papers

Synthesis method of synthetic intermediate methyl phosphite monoester of glufosinate ammonium

The invention belongs to the technical field of synthesis of glufosinate ammonium and in particular relates to a synthesis method of a synthetic intermediate methyl phosphite monoester of glufosinateammonium. Aiming at the common problem of an existing methyl phosphite monoester synthesis method that the cost is too high so that the existing methyl phosphite monoester synthesis method is not applicable to large-scale industrial production, the synthesis method provided by the technical scheme comprises the following steps: [1], enabling methylphosphonothioic dichloride to react with a hydroxyl compound under the action of an alkali A, so as to obtain diethyl methylphosphonothionate; [2], dissolving the diethyl methylphosphonothionate into a solvent B to prepare a diethyl methylphosphonothionate solution; carrying out hydrolysis reaction under the action of an alkali B to generate methylphosphonothioic monoester; [3], dissolving the methylphosphonothioic monoester into a solvent C to prepare a methylphosphonothioic monoester solution; carrying out desulfurization reaction on the methylphosphonothioic monoester solution under the action of a catalyst to prepare the methyl phosphitemonoester. The synthesis method provided by the invention is applicable to a glufosinate ammonium synthesis industry.

Detoxification of O, S-diethyl methyl phosphonothiolate (OSDEMP), a simulant of VX, by N, N-dichlorourethane as an effective decontaminating agent

N, N-Dichlorourethane has been synthesized and characterized by FT-IR, NMR. Efficiency of this compound as decontaminant has been evaluated by the reaction of O, S-diethyl methyl phosphonothiolate (OSDEMP), a simulant of VX at RT. The decontamination reaction has been monitored by gas chromatography (GC) and the products have been identified by GC-MS.