180145-03-3

Upstream product

• 4235-20-5 5-chloro-2-phenylsulfanyl-aniline 
• 625-36-5 2-chloropropionyl chloride 
• 101096-34-8 N-(3-chloropropyl)-5-chloro-2-phenylthiophenylamine 

Downstream Products

• 61414-38-8 3-(N-(2-phenylthio-5-chloro)phenyl)propyldimethylamine 
• 180145-13-5 {3-[4-(2-Amino-ethyl)-piperazin-1-yl]-propyl}-(5-chloro-2-phenylsulfanyl-phenyl)-amine 
• 180145-05-5 N-(2-Amino-ethyl)-N'-(5-chloro-2-phenylsulfanyl-phenyl)-propane-1,3-diamine 
• 180145-04-4 (5-Chloro-2-phenylsulfanyl-phenyl)-(3-iodo-propyl)-amine 

Relevant academic research and scientific papers

Diaryl sulfide-based inhibitors of trypanothione reductase: Inhibition potency, revised binding mode and antiprotozoal activities

Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas′ disease. Diaryl sulfides with a central anilino moiety, decorated with a

2-Amino diphenylsulfides as inhibitors of trypanothione reductase: Modification of the side chain

A molecular modeling study meant to detect pharmacophore-like patterns in the active site of trypanothione reductase (TR) offered hints about the opportunity of synthesizing and testing diphenylsulfide derivatives with prolonged or branched polyamino side chains as putative TR inhibitors. The inhibition results within the synthesized series confirmed the main working hypothesis inspired by the molecular modeling study. The different compounds were tested in vitro on the enzyme and on Trypanosama cruzi and Trypanosoma brucei trypomastigotes as well as in vivo in infected mice.