180187-58-0Relevant academic research and scientific papers
The use of 2-O-propagyloxycarbonyl protecting group in the selective formation of 1,2-trans-glycosidic linkage
Sato, Ken-ichi,Sakai, Koudai,Kojima, Masaru,Akai, Shoji
, p. 4423 - 4425 (2007)
The effect of N-phenylcarbamoyl (Car) and propagyloxycarbonyl (Poc) protecting groups at the O-2 position of donors was examined. The usefulness of Poc group in the selective formation of 1,2-trans-glycosidic linkage is shown by comparing the reactivity o
Practical and efficient large-scale preparation of dimethyldioxirane
Mikula, Hannes,Svatunek, Dennis,Lumpi, Daniel,Gloecklhofer, Florian,Hametner, Christian,Froehlich, Johannes
, p. 313 - 316 (2013)
An improved procedure for large-scale and also commercially viable preparation of dimethyldioxirane (DMDO), a common and widely used oxidation agent in organic synthesis, was developed using a conventional laboratory plant. All reaction parameters were optimized, and the stability of a freshly prepared solution of DMDO in acetone was monitored over an extended period of time to ensure long-term use after preparation, transport, and storage. This discontinuous approach, suitable for batch processing, is of interest basically to research laboratories but also to suppliers in the research and fine chemicals market.
Picoloyl protecting group in synthesis: Focus on a highly chemoselective catalytic removal
Bandara, Mithila D.,Demchenko, Alexei V.,Geringer, Scott A.,Mannino, Michael P.
, p. 4863 - 4871 (2020/07/13)
The picoloyl ester (Pico) has proven to be a versatile protecting group in carbohydrate chemistry. It can be used for the purpose of stereocontrolling glycosylations via an H-bond-mediated Aglycone Delivery (HAD) method. It can also be used as a temporary protecting group that can be efficiently introduced and chemoselectively cleaved in the presence of practically all other common protecting groups used in synthesis. Herein, we will describe a new method for rapid, catalytic, and highly chemoselective removal of the picoloyl group using inexpensive copper(ii) or iron(iii) salts. This journal is
2-: O-Benzyloxycarbonyl protected glycosyl donors: A revival of carbonate-mediated anchimeric assistance for diastereoselective glycosylation
Weber, Julia,Svatunek, Dennis,Krauter, Simon,Tegl, Gregor,Hametner, Christian,Kosma, Paul,Mikula, Hannes
, p. 12543 - 12546 (2019/10/28)
By reviving an old idea, we demonstrate that alkoxycarbonyl groups can be used in glycosylation reactions to achieve full stereocontrol through participation of a carbonate moiety at O-2. Various benzyloxycarbonyl-protected glycosyl donors were prepared and used for efficient 1,2-trans glycosylation of base-labile compounds and the synthesis of glycosyl esters.
Contribution of phosphates and adenine to the potency of adenophostins at the IP3 receptor: Synthesis of all possible bisphosphates of adenophostin A
Sureshan, Kana M.,Riley, Andrew M.,Thomas, Mark P.,Tovey, Stephen C.,Taylor, Colin W.,Potter, Barry V. L.
supporting information; experimental part, p. 1706 - 1720 (2012/05/04)
Although adenophostin A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP3R), is thought to mimic IP 3, the relative roles of the different phosphate groups and the adenosine motif have not been established. We synthesized all three possible bisphosphate analogues of AdA and glucose 3,4-bisphosphate (7, AdA lacking the 2′-AMP). 2′-Dephospho-AdA (6) was prepared via a novel regioselective dephosphorylation strategy. Assessment of the abilities of these bisphosphates to stimulate intracellular Ca2+ release using recombinant rat type 1 IP3R (IP3R1) revealed that 6, a mimic of Ins(4,5)P2, is only 4-fold less potent than IP3, while 7 is some 400-fold weaker and even 3′3-dephospho-AdA (5) is measurably active, despite missing one of the vicinal bisphosphate groups normally thought to be crucial for IP3-like activity. Compound 6 is the most potent bisphosphate yet discovered with activity at IP3R. Thus, adenosine has a direct role independent of the 2′-phosphate group in contributing toward the potency of adenophostins, the vicinal bisphosphate motif is not essential for activity at the IP3R, as always thought, and it is possible to design potent agonists with just two of the three phosphates. A model with a possible adenine-R504 interaction supports the activity of 5 and 6 and also allows a reappraisal of the unexpected activity previously reported for the AdA regioisomer 2′3-phospho-3′3- dephospho-AdA 40.
Comparative solution and solid-phase glycosylations toward a disaccharide library
Agoston, Karoly,Kroeger, Lars,Agoston, Agnes,Dekany, Gyula,Thiem, Joachim
experimental part, p. 1428 - 1433 (2009/12/05)
A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The
How the arming participating moieties can broaden the scope of chemoselective oligosaccharide synthesis by allowing the inverse armed-disarmed approach
Smoot, James T.,Demchenko, Alexei V.
supporting information; experimental part, p. 8838 - 8850 (2009/04/05)
(Chemical Equation Presented) A new method for stereocontrolled glycosylation and chemoselective oligosaccharide synthesis has been developed. It has been determined that complete 1,2-trans selectivity can be achieved with the use of a 2-O-picolyl moiety,
A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant
Wang, Zhi-Guang,Warren, J. David,Dudkin, Vadim Y.,Zhang, Xufang,Iserloh, Ulrich,Visser, Michael,Eckhardt, Matthias,Seeberger, Peter H.,Danishefsky, Samuel J.
, p. 4954 - 4978 (2007/10/03)
The total synthesis of an H-type blood group determinant in a model biological setting is described. The construct is comprised of a high mannose core structure with projecting lactose spacers, culminating in a two-copy presentation of the H-type blood group determinant itself. Key reactions that were used in this construction include sulfonamidohydroxylation (see 15→18) and benzoate-directed glycosylation via an activated thiophenyl donor (see 34→36). Another key strategic element involved the epimerization of an interior core glucoside to reach the β-mannoside (see 37→38) required in the ring C sugar of the high mannose core.
A highly convergent total synthetic route to glycopeptides carrying a high-mannose core pentasaccharide domain N-linked to a natural peptide motif
Danishefsky, Samuel J.,Hu, Shuanghua,Cirillo, Pier F.,Eckhardt, Matthias,Seeberger, Peter H.
, p. 1617 - 1628 (2007/10/03)
N-Linked glycopeptides were synthesized by condensation of a high-mannose anomeric amine bearing a pentasaccharide with aspartic-acid-containing tri- and pentapeptides through the agency of IIDQ. The pentasaccharide portion, corresponding to the 'core' re
Coupling of glycal derived thioethyl glycosyl donors with glycal acceptors. An advance in the scope of the glycal assembly
Seeberger, Peter H.,Eckhardt, Matthias,Gutteridge, Clare E.,Danishefsky, Samuel J.
, p. 10064 - 10072 (2007/10/03)
Glycals were converted into thioethyl glycosyl donors through 1,2-anhydrosugar intermediates. Various participating groups in the C-2 position were examined for formation of β-glucosyl, β-galactosyl, and α-mannosyl linkages. A number of disaccharides was
