180198-96-3Relevant academic research and scientific papers
Synthesis of tricyclic aryl spiroacetals related to the papulacandins
Brimble, Margaret A.,Robinson, Stuart G.
, p. 9553 - 9562 (1996)
A convenient synthesis of aryl spiroacetals related to the antifungal agents, the populacandins, is reported. The synthetic methodology involves the addition of ortho-lithiated diethylbenzamides to lactones followed by acid catalysed cyclization of the resultant keto-alcohols.
