
Tetrahedron p. 9553 - 9562 (1996)
Update date:2022-08-03
Topics:
Brimble, Margaret A.
Robinson, Stuart G.
A convenient synthesis of aryl spiroacetals related to the antifungal agents, the populacandins, is reported. The synthetic methodology involves the addition of ortho-lithiated diethylbenzamides to lactones followed by acid catalysed cyclization of the resultant keto-alcohols.
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Doi:10.1021/jm301367c
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