180200-86-6

Usage

Uses

Used in Pharmaceutical Development:
4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE is used as a research compound for the development of new pharmaceutical drugs, particularly for conditions that require modulation of neurotransmitter levels.
Used in Antidepressant and Anxiolytic Medications:
In the pharmaceutical industry, 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE is used as a selective serotonin and norepinephrine reuptake inhibitor for the treatment of depression and anxiety disorders, due to its ability to modulate neurotransmitter levels in the brain.
Used in Pain Management:
4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE is used as a potential analgesic agent for the management of pain, given its demonstrated properties in this area of research.
Used in Neurological Disorder Treatment:
In the field of neurology, 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE is used as a candidate for the treatment of various neurological disorders, leveraging its potential to influence neurotransmitter reuptake mechanisms.

InChI:InChI=1/C8H8BrClO2S/c1-13(11,12)7-3-2-6(5-9)8(10)4-7/h2-4H,5H2,1H3

Upstream product

• 181300-40-3 [2-chloro-4-(methylsulfonyl)phenyl]methanol 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 101349-95-5 2-chloro-4-(methylsulfonyl)benzaldehyde 

Downstream Products

• 932708-12-8 3-(2-chloro-4-methanesulfonylbenzyl)pentane-2,4-dione 
• 932708-60-6 2-(2-chloro-4-methanesulfonylbenzyl)-3-oxopentanoic acid methyl ester 
• 1033951-24-4 4-{2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 
• 1033951-08-4 4-{5-Bromo-2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 
• 918524-57-9 [3-(2-chloro-4-methanesulfonyl-benzyloxy)-2-ethoxy-phenyl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone 
• 1021873-50-6 5-chloro-1-[2-chloro-4-(methylsulfonyl)benzyl]-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide 
• 1033954-30-1 (E)-3-(4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-phenyl)-acrylonitrile 
• 1033954-34-5 4-{2-[8-(2-chloro-4-methanesulfonyl-benzyl)-8-aza-bicyclo[3.2.1]oct-3-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-benzonitrile 
• 1034013-11-0 4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-ylamino}-3,5-dimethyl-benzonitrile 
• 1033951-84-6 4-{2-[1-(2-Chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-5-fluoro-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile 
• 1033951-66-4 3-Chloro-4-{2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-5-methyl-benzonitrile 
• 1394070-52-0 2-chloro-5-(2-chloro-4-(methylsulfonyl)benzyl)-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridine 

Relevant academic research and scientific papers

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma

Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compou

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

USE OF PYRROLO [2 , 3-B] PYRIDINES TO PREPARE A MEDICAMENT FOR TREATING PAIN

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use in the manufacture of a medicament for the treatment of neuropathic pain.

ORGANIC COMPOUNDS

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.