18023-29-5Relevant academic research and scientific papers
Pyrrole chemistry. XXIII. The cyanation of substituted pyrroles with chlorosulfonyl isocyanate (CSI). New syntheses of pyrrole-3-carbonitriles
Loader, Charles E.,Anderson, Hugh J.
, p. 2673 - 2676 (2007/10/02)
Chlorosulfonyl isocyanate (CSI) reacts not only with pyrrole itself but with pyrroles having powerful electron-withdrawing groups in the 2-position.Suitable choice of electron-withdrawing groups allows selective 4-substitution of the pyrrole ring.The N-chlorosulfonyl amides formed are readily converted to the corresponding nitriles.The procedure has been used to provide syntheses of pyrrole-3-carbonitrile and its 1-methyl homologue.
